Appalachian Wellness Center PLLC

04/27/2023

10/15/2021

We’ve discovered a new approach to treating MARCoNS. Nasal povidone-iodine has been found to be very effective in wiping out germs of the nasal passages. Numerous studies have shown that iodine acts as a mucolytic and an antiseptic which can break down the biofilms associated with MARCoNS. This alternative treatment is as safe as and less expensive than regimens we've used in the past. We now recommend our patients use 1 month of Lodine iodine swabs, followed by 1 month of a probiotic microbial spray called LiviaOne. Both can be found on Amazon.

Here are links to several of the studies that support this

the Nasopharynx and Oropharynx With Chlorhexidine Gluconate
A Randomized Controlled Trial
https://jamanetwork.com/journals/jama/article-abstract/204276

Methicillin-Resistant Staphylococcus aureus Infection and Treatment Options
https://link.springer.com/protocol/10.1007/978-1-4939-9849-4_16

Efficacy of Skin and Nasal Povidone-Iodine Preparation against Mupirocin-Resistant Methicillin-Resistant Staphylococcus aureus and S. aureus within the Anterior Nares
https://journals.asm.org/doi/full/10.1128/AAC.04624-14

Preventing Surgical Site Infections: A Randomized, Open-Label Trial of Nasal Mupirocin Ointment and Nasal Povidone-Iodine Solution
https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/abs/preventing-surgical-site-infections-a-randomized-openlabel-trial-of-nasal-mupirocin-ointment-and-nasal-povidoneiodine-solution/F3E17F2F69DBC6B6E702C676A8415FF6

Preventing Surgical Site Infections: A Randomized, Open-Label Trial of Nasal Mupirocin Ointment and Nasal Povidone-Iodine Solution - Volume 35 Issue 7

07/09/2021

Need an energy boost to get out there and take advantage of this beautiful Appalachian summer weather??

Come see us at Appalachian Wellness for an IV Energy Drip! Our special 'cocktail' of vitamins and fluids will give your body the boost it needs so you can get up, get out, and enjoy the day!

Your first Energy drip is only $69! And we offer freebies and discounts to our repeat customers!

Come check out all of our incredible IV drips! They are individually mixed for you specifically and can be modified to address your specific needs- custom 'cocktails' are our specialty!
https://appwell.net/iv-services/

07/09/2021

They say, "laughter is the best medicine", here's your daily Rx:
😜😄😁😆😆

07/09/2021

Lyme test results can be difficult to understand and physicians may have vastly different interpretations of the same results. This pic is a cheat sheet of the most significant bands in the Western Blot test to a positive Lyme diagnosis.

Remember: testing negative for Lyme does not definitively mean that you have not had Lyme or that you are not suffering from chronic Lyme.

The best diagnosis is made using physical exam, history, presentation, symptom screening, as well as lab values! Complex conditions, complex assessment!

I recommend having a LLMD interpret Lyme testing whenever possible!

07/09/2021

https://appwell.net/cistus-tea-or-how-to-become-repulsive-to-ticks/

Protect yourself and your best furry friends! What can't this tea do??

05/27/2021

The FDA has recently decided to pull non-prescription access to NAC for US citizens. The product is rapidly disappearing from sites across the internet, with a notable absence on Amazon. If you utilize this supplement, now is the time to buy! Stock up and have it handy. There is a fight going on regarding this decision, and the ultimate outcome is yet to be seen. Times of uncertainty call for increased preparation. The following links are two sites I found it on yesterday at good prices.

https://www.lifeextension.com/vitamins-supplements/item01534/n-acetyl-l-cysteine?gclid=CjwKCAjw47eFBhA9EiwAy8kzNGYa69qJqL954l5S1EiEb_l0g8hGgGFet8UUzPFhicUMapTW_83sqRoCVMoQAvD_BwE

https://www.pureformulas.com/campaign/default/shop-all-NAC.html?view=listing&CAWELAID=530005240008817503&CATRK=SPFID-1&CAAGID=97069024541&CATCI=kwd-53246267&CAPCID=431343069006&CADevice=c&gclid=CjwKCAjw47eFBhA9EiwAy8kzNHDsYx5YCEpSOb8GBLmU-ctZxN9758jYb1_7qJBvmxmPmVzNyOooZxoChtcQAvD_BwE

Check out this promotion from PureFormulas, where you can save on a variety of nutritional supplements and products to help you live a healthier life.

05/16/2021

Akili Collaborates with Weill Cornell Medicine, NewYork-Presbyterian Hospital and Vanderbilt University Medical Center to Study Digital Therapeutic AKL-T01 as Treatment for Patients with COVID Brain Fog
AKL-T01 is the first and only digital therapeutic specifically designed to improve attention function

Screenshot of AKL-T01 gameplay (Graphic: Business Wire)

April 07, 2021 05:00 AM Eastern Daylight Time

BOSTON--(BUSINESS WIRE)--Akili Interactive (“Akili” or “Company"), today announced collaborations with Weill Cornell Medicine, NewYork-Presbyterian Hospital and Vanderbilt University Medical Center to evaluate Akili digital therapeutic AKL-T01 as a treatment for patients with cognitive dysfunction following COVID-19 (also known as “COVID brain fog”). There are currently no approved treatments for cognitive impairments in COVID-19 survivors.

“With more than 100 million infections globally and counting, the potential impact of long-term cognitive impairments in even a subset of these patients is devastating. We look forward to working with leading researchers at Vanderbilt, Weill Cornell and NewYork-Presbyterian to understand and improve COVID-19-related cognitive deficits.”

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Under each collaboration, Akili will work with research teams at each institution to conduct two separate randomized, controlled clinical studies evaluating AKL-T01’s ability to target and improve cognitive functioning in COVID-19 survivors who have exhibited a deficit in cognition. AKL-T01 is the first and only digital therapeutic specifically designed to improve attention function. The organizations aim to begin clinical recruitment for the studies in the next month.

“As frontline healthcare workers continue to fight the immediate acute symptoms of COVID-19, certain longer-term consequences of the illness are beginning to emerge, including serious cognitive impairments,” said Anil S. Jina, M.D., Chief Medical Officer at Akili. “With more than 100 million infections globally and counting, the potential impact of long-term cognitive impairments in even a subset of these patients is devastating. We look forward to working with leading researchers at Vanderbilt, Weill Cornell and NewYork-Presbyterian to understand and improve COVID-19-related cognitive deficits.”

Since being named a global pandemic by the World Health Organization in March 2020, clinicians continue to learn about the vast ways in which COVID-19 manifests in patients. Evidence is mounting on long-term neurological and cognitive symptoms that can persist in some COVID-19 patients after initial diagnosis, even after the virus is no longer detected in the body. A study published in Neuropsychopharmacology led by Drs. Abhishek Jaywant and Faith Gunning at Weill Cornell Medicine and NewYork-Presbyterian found that difficulties in attention, multitasking, and processing speed were common in hospitalized patients recovering from COVID-191. Of the patients in their study, 81% exhibited some degree of cognitive impairment1. Recent research also shows these cognitive impairments may persist post-hospitalization and commonly occur in “post-COVID long haulers” or “long COVID” patients. These impairments can have a significant impact on survivors’ daily functioning and quality of life, impacting the ability of most COVID-19 long haulers to work for six months or more according to a recent study2. For more information on COVID brain fog, click here.

“Clinicians are seeing an increase in cognitive impairments among COVID-19 patients and though we don’t yet know how long these difficulties last, we are concerned about how these cognitive difficulties may affect people in their daily lives,” said Gunning Ph.D., Vice Chair of Research in the Department of Psychiatry, associate professor of psychology in psychiatry at Weill Cornell Medicine, and associate attending psychologist at NewYork-Presbyterian/Weill Cornell Medical Center, who is the study coordinator. “It’s critical that we identify therapeutics to help the increasing number of people whose lives have been impacted by cognitive impairments associated with COVID-19.”

“The chronic symptoms of COVID-19 long haulers represent a serious and growing public health concern that will linger long after the acute nature of COVID-19 has passed,” said James Jackson, PsyD, Assistant Director of The ICU Recovery Center at Vanderbilt and lead psychologist for the Critical Illness, Brain Dysfunction and Survivorship (CIBS) Center at the Vanderbilt University Medical Center. “We’re excited by the potential of new therapeutics that target cognitive impairments to help COVID-19 survivors.”

AKL-T01 is built on the Akili Selective Stimulus Management Engine (SSMETM), a disease agnostic proprietary technology designed to treat impaired cognitive function, specifically attention control. Delivered through an action video game experience, the first-in-class technology presents specific sensory stimuli and simultaneous motor challenges designed to target and activate the neural systems that play a key role in attention function while using adaptive algorithms to personalize the treatment experience for each individual patient. SSME has been evaluated as a potential treatment for cognitive impairments associated with a number of different disease areas and has been studied in more than 2600 patients across 30 clinical trials. AKL-T01, branded EndeavorRxTM, is cleared for use by the U.S. Food and Drug Administration (FDA)3 and has received Conformité Européenne (CE) Mark certification in Europe for use in pediatric ADHD4. Product screenshots and b-roll are available here.

Study Designs
The Akili, Weill Cornell Medicine and NewYork-Presbyterian Hospital randomized, controlled study will evaluate AKL-T01 in approximately 100 COVID-19 survivors ages 18-89 who have exhibited a deficit in cognition. The study will take place over 10 weeks, with 6 weeks of treatment and 4 weeks of follow-up. Half of the study participants will receive the digital treatment and half will serve as a control group. The primary endpoint of the study is mean change in cognitive function, as assessed by a measure of attention and processing speed. Secondary endpoints include additional measures of cognitive functioning. The study will be conducted remotely in patients’ homes, and patients in the control arm will have the option to receive the AKL-T01 intervention after the conclusion of their participation in the control condition.

The Akili and Vanderbilt randomized, controlled study will evaluate AKL-T01 in approximately 100 COVID-19 survivors ages 18 and older who have exhibited a deficit in cognition. The study will recruit from subjects who have completed the SARS-CoV-2 Household Transmission Study. Half of the study participants will receive the digital treatment for 4 weeks and half will serve as a control group. The primary endpoint of the study is mean change in cognitive function, as measured by CNS Vital Signs (composite score of cognitive function, especially attention and processing speed). Secondary endpoints include additional measures of cognitive functioning. The study will be conducted remotely in patients’ homes.

About Akili
Akili is combining scientific and clinical rigor with the ingenuity of the tech and entertainment industries to challenge the status quo of medicine. Akili has pioneered the development of video game-based digital medicine to improve cognitive function. Akili’s flagship product is a prescription digital treatment to address inattention in children with attention deficit hyperactivity disorder (ADHD). Akili’s patented technology serves as the foundation of its products and is designed to directly activate the networks in the brain responsible for cognitive function. Driven by Akili’s belief that effective medicine can also be fun and engaging, Akili’s treatments are delivered through captivating action video game experiences that drive engagement and compliance. For more information, please visit AkiliInteractive.com.

1 Jaywant et al. Neuropsychopharmacol. (2021).

2 David et al. Preprint. (2020).

3 EndeavorRx is an FDA-cleared medical device. It is indicated to improve attention function as measured by computer-based testing in children ages 8-12 years old with primarily inattentive or combined-type ADHD, who have a demonstrated attention issue. Patients who engage with EndeavorRx demonstrate improvements in a digitally assessed measure Test of Variables of Attention (TOVA) of sustained and selective attention and may not display benefits in typical behavioral symptoms, such as hyperactivity. EndeavorRx should be considered for use as part of a therapeutic program that may include clinician-directed therapy, medication, and/or educational programs, which further address symptoms of the disorder. EndeavorRx is available by prescription only. It is not intended to be used as a stand-alone therapeutic and is not a substitution for a child’s medication.

4 In June 2020, EndeavorRx received Conformité Européenne (CE) Mark certification as a prescription-only digital therapeutic software intended for the treatment of attention and inhibitory control deficits in pediatric patients with ADHD.

Contacts

Julie DiCarlo
julie@akiliinteractive.com

05/02/2021

https://conta.cc/3tir0ww

You don't want to miss this. Appalachian Wellness Ctr PLLC 200 District Dr. Asheville, NC 28803-0235 (828) 785-1850V (828) 785-1802F www.AppWell.net A New Website Has Been Born! Greetings! We are Thri

05/02/2021

CIRSLife.org has launched! This site is not part of Appalachian Wellness Ctr PLLC, it's dedicated to all who suffer from long-term complex chroninc illnesses (CCI) such as CIRS, Mast Cell Activation Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Chronic Lyme and so many others.
PLEASE! Check it out if you suffer from this, or if loved ones do, refer them to it.
The first questionnaire form online deals with their needs and demographics, it leads to a second questionnaire regarding their own medical history & symptoms. Once the second form is done the respondent gets an EMail listing their scores and likelihood of having some of these various illnesses and guides them as to where they can find help from knowledgable practitioners.
The third part of the questionnaire provides a free test & discounted future tests from www.VCSTest.com. This test looks out at how well their mitochondria are working.
The site is anticipated to be live and online for about a year, after which we hope to write a paper in the peer-reviewed medical and scientific journals about the actual incidence of these illnesses that are so poorly understood and often undiagnosed.
Unfortunately, most physicians are untrained in this area and just don't think of these illnesses that they are poorly equiped to treat.

We need to change that! Data is the key. You have the gold, we need to mine your gold to effect changes and awareness.

We need your help!

So please, take a few minutes of your time. Go to www.CIRSLife.org, fill out a couple of online questionaires, get a response EMail with clues from validated tests as to what is wrong with you, get information on where to get help and a free VCS test to evaluate how well your mitochondria are doing.

Get on a validated road to recovery. We don't sell anything here. We're only going to use your de-identified data for research, this is a nonprofit looking only for your information so that we can help you and the many others like you.
Thank you for taking the time to review this post, we wish you all the best in your recovery & healing!

Welcome to CIRS Life A website dedicated to identifying those afflicted with Chronic Inflammatory Response Syndrome (CIRS) and/or other "Complex Chronic Illnesses" View Printable Version CIRSLife is a website dedicated to identifying those afflicted with Chronic Inflammatory Response Syndrome (CIRS)...

03/15/2021

https://www.lymedisease.org/five-herbal-medicines-babesia/
Interesting!

Researchers tested 46 herbs against B. duncani in the lab--and found five of them worked better than standard treatment against the parasite.

03/04/2021

https://www.crimeoflymemovie.com/

Great project in the works! Will really spread awareness and understanding of the severity and prevalence of Lyme disease! Consider donating!

03/03/2021

https://youtu.be/U0isk_Ox82U

A funny, evidence based and easy explanation of ozone therapy! Check it out.
Dr. Oenbrink offers multiple ozone therapies in his practice! Call us and let's discuss how Ozone therapy can help you heal and improve your health!

Click to access the protocols: https://drsozone.com/a/blog/2021-protocols-for-ozone-therapyWe have done the legwork to put together an update and easy to und...

03/02/2021

Free event on the connection between autoimmunity, food sensitivities, and EMF sensitivity! Check it out!

01/10/2021

Tick bites can often go unnoticed, but the chronic effects of Lyme are felt to varying degrees for years following infection. Protecting exposed skin when enjoying the outdoors and doing a full body tick check upon returning inside can reduce your risk of a bite- be sure to check your children too! Scalp to toes. Check out this video from the global Lyme Alliance (globallymealliance.com.) Stay safe and practice joy!

⛺️🏔⛰

12/17/2020

Hello all! Appalachian Wellness Center is proud to now be offering a wide range of nutritional and hydrational IV infusion, injections, and ozone therapies! Please see the list of offerings on our web page! Each can be customized to meet your specific needs/concerns. Rejuvenating and replenishing! You won't regret it!

11/27/2020

Oxytocin; The “Feel Good” Hormone–here’s what it does & how it works!
by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, Lyme Disease & Atypical Infections, Mast Cell Activation Syndrome, Multiple Chemical Sensitivity (MCS)

Oxytocin
Oxytocin
Many of us have heard of it as the “feel good hormone”, it’s release is triggered as a mother nurses her infant–triggering maternal-infant bonding. It’s released when we fall in love with somebody as well. For folks with diabetes insipidus–a condition unrelated to blood sugar, but found when the kidneys do not concentrate urine adequately, oxytocin can help increase the kidney concentrating power to save water.

We commonly see diabetes insipidus in complex chronic illnesses such as Chronic Inflammatory Response Syndrome (CIRS), Chronic Fatigue Syndrome, Chronic Lyme, and similar complex illnesses. When used as an intra-nasal spray, it can correct the renal deficiency allowing the kidneys to concentrate urine properly.

Table of Contents [show]

Oxytocin has a variety of other beneficial effects;
Promotes emotional attachment.
Solidifies relationships.
Crystallizes emotional memories.
Facilitates childbirth & breast feeeding.
Increases sexual arousal.
Reduces cravings for illicit drugs.
Improves social skills.
Triggers protective instincts.
Induces sleep.
Reduces stress.


Stress reduction is a big benefit of oxytocin
–especially when suffering from a complex chronic illness such as those above. A scientific article from 2003; Social Support and Oxytocin Interact to Suppress Cortisol and Subjective Responses to Psychosocial Stress explores how this happens at the biochemical level. Oxytocin directly effects the adrenal glands to accomplish this.

“Cushing’s Syndrome” occurs in complex chronic illnesses. This causes the adrenal glands to produce excessive amounts of cortisol which is normally reduced with inflammation and stress–so it’s not surprising that the inflammation & stress in a complex chronic illness would do this.

The “Cushings” cortisol response is also common in the autonomic nervous system’s sympathetic “fight or flight” state–which these diseases lock the brain into.

Unfortunately, the adrenal glands eventually “burn out” leading to low cortisol in the face of excessive demand, known as “Addison’s Disease”–a very unhealthy situation as the coping mechanisms are now lost.

It’s important to do a “manual reset” of sorts in the brain, to switch from the Sympathetic to the Parasympathetic “heal & renew” state where healing will occur.

Now that we understand the benefits of Oxytocin in reducing the need for high outputs of cortisol, there are other ways to augment this recovery from excess sympathetic stimulation:

Dynamic Neural Retraining System (DNRS)
Annie Hopper has produced a system for retraining the brain to promote healing; https://retrainingthebrain.com or (800) 947-9389 which can be purchased as a DVD set for $250. The Autonomic Nervous System consists of the Sympathetic “fight or flight” & Parasympathetic “Grow & Heal” divisions. Her Dynamic Neural Retraining System (DNRS) helps to put the brain (& thus the rest of the body) back into the correct balance for healing, accelerating recovery from CIRS, Mast Cell Activation Syndrome (MCAS), Multiple Chemical Sensitivity (MCS) & ElectroMagnetic Field Sensitivity (EMF) among other chronic complex illnesses. Her system has a proven track record. I highly recommend it to help speed (and in severe cases simply enable) recovery.

Heartmath is another solution for $150.00
There are also several articles to help boost parasympathetic activity.
So; the upshot of all of this is that switching from a sympathetic to a parasympathetic state allows for faster healing and recovery from complex chronic illnesses. There are many ways we can do this allowing for a more rapid recovery.

11/27/2020

New Relief for the Aches & Pains of CIRS & Lyme
by Dr. Raymond Oenbrink | CIRS, Functional & Integrative Medicine, Lyme Disease & Atypical Infections

There is new hope for those of us who suffer from joint aches & pains related to CIRS & Lyme disease.
Table of Contents [show]

As described in the Clinical Review of Medical Ozone.
Ozone can provide relief of chronically inflamed joints, bursae (fluid filled cavities overlying bone where tendon or muscle must pass over the bone–like a pulley), ligaments (connective tissue between bones) & tendons (connective tissue between muscle & bone).

Prolotherapy involves injections of substances that promote healing of the injured area.
There are a variety of substances that we can use for this. I’ve personally received ozone treatment for Lyme-related arthritis with good effects. By this, I mean relief of pain, reduction of excessive fluid in the joint (effusions) that prevented my knees from fully flexing (think of trying to bend a hinge against a tough water balloon in the way). The effusions lessened or resolved but the best part was the immediate pain relief! Part of the healing involves fibroblasts laying down more collagen to re-strengthen the involved areas to their pre-damage (or better) state.

Lyme and other tick-borne illnesses can grow in joints, and other tissues causing local pain & destruction of those joints.
Frequently with Lyme, the “migrating pain” presents. Today perhaps my right knee hurts, tomorrow (or even later today), it may be my left ankle. Although it’s a difficult process to determine the mechanism of each area, it appears that cytokines–intercellular chemical messengers are actively causing inflammation.

Inflammation can be a double-edged sword.
Short-term inflammation can be good–bringing white blood cells and other immune components to the area of inflammation to help eliminate infection. Sometimes however-the infection is not easily eliminated. Inflammation becomes chronic. Chronic inflammation also damages joints, tendons, bursae–whatever tissue it is present in.

Lyme-related inflammation can wax and wane over time.
This helps us understand why joint aches and pains come and go. Borrelia burgdorferi, the causative microbe for Lyme is able to “hide” inside the cells of the host, away from it’s immune system ongoing surveillance. Borrelia and many other tick-borne microbes are “microaerophilic” organisms. What does that mean? It only tolerates a little bit of oxygen, to much oxygen is toxic and kills the organism. Ozone increases the oxygen carrying capacity of hemoglobin ten-fold! Putting that much oxidation power in the joint or other tissue area inhabited by these germs. While killing the germs, it also acts as a prolotherapy agent–promoting healing of the damaged tissues–AND providing pain relief!

Pain doesn’t always disappear in the initial session, but improvements are generally noted.
“Ten miles into the woods means ten miles out of the woods”. The longer somebody has been sick, the more these microbes have been multiplying in their host (you). The larger the total toxic burden of disease, the more time can be expected before full healing and recovery occurs–but it will–with appropriate therapy!

How often is this done and for how long a period of time?
As with so many things in the practice of medicine, the patient’s response to treatment provides guidance as to how often it needs to be done and for how long. Typically it can be done as often as a few times per week to an involved area–until that area is doing better. Some areas will resolve with only one procedure, others will require repetitive treatments, the frequency and amount based on the patient’s response to therapy.

Are there risks, contraindications, potential problems and side effects?
Certainly accidents can happen. One should always avoid injecting a needle into a joint through infected skin. The biggest problems with injecting joints are infection of the joint, damage to structures within the joint by the needle–which typically heal uneventfully but may worsen pain in the short-term, inadvertent puncture of a blood vessel causing bleeding, nicking a nerve–which exist in skin, joint capsules, bone and would cause pain and perhaps numbness for awhile until it heals. An experienced clinician will know how to avoid these pitfalls. It seems counter-intuitive to inject a gas (ozone is a gas) into a joint–concerns about an air embolism that can migrate in the body are largely unfounded because ozone is so soluble in blood–the gas is absorbed into blood and other cells almost instantaneously as the injection is done–the joint space will briefly billow out a bit then immediately go back to normal size. For those worried about pain we can add a pain relieving agent like lidocaine or bupivacaine to provide instant relief of any discomfort–with the added bonus of letting us know that we “hit the right spot”.

What parts of the body benefit from ozone?
Autohemotransfusion procedure involves the extraction of 200 ml venous blood into heparin (25 IU/ml) and CaCl2 (5mM). In a sterile single-use 300 ml container, the blood was mixed with 200 ml of the O3/O2 gas mixture at a concentration of 60 μg/ml and then slowly reintroduced into the patient. The blood was extra-corporeal for 15–30 min and there were no adverse reactions except hematoma formation in the area of venous injection.
Re**al insufflation was employed when the performance status was low, or at the preference of patient. This procedure consisted in re**al insufflation of 300 ml of O3/O2 gas mixture at a concentration of 60 μg/ml. The main side effects were transient meteorism and constipation in some patients. Due to its high solubility, the ozone rapidly transits across the colonic mucosa into the portal circulation and through the liver to enter systemic circulation.
Ozone can also be insufflated into the vaginal cavity, nasosinus cavities and external ear canals by allowing the ozone generator to fill a low-pressure reservoir that is then attached to a canula which is inserted into the appropriate body cavity of choice for insufflation. Ozone has been safely instilled into the bladder, pleural & peritoneal cavities as well.
Ozone can be safely injected into tissues as well. These include areas such as the
temporomandibular joint.
Ozone can be used to treat intra-thecal tears of the lumbar spinal discs as well as lumbar disc herniations, some of this effect involves modulation of inflammatory cytokines in the area. This technique involves imaging equipment that we do not have at this point.
Cervical disc herniations are also amenable to treatment with ozone.
Carpal tunnel syndrome can be improved with injection of 4 cc of ozone and 1 cc of lidocaine directly into the space.
Supraspinatus tendon tears < 1.5 cm in length have been shown to heal with ultrasound-guided injection of ozone into the peri-tendon sheath.
Rheumatoid arthritis treatment with ozone in rats seems optimal at a concentration of 40 µg/mL when injected intra-articularly into the involved joints.
Scleroderma is another systemic connective tissue autoimmune inflammatory disease that shows thermographic improvements after ozone therapy.
Fibromyalgia patients also receive relief from ozone therapy via a variety of mechanisms including antioxidant, immune modulation and mitochondrial effects.
Topically, ozone can be placed directly into an impermeable container such as a bag in which an extremity is encased for topical treatment of wounds and skin. Additionally, it can be bubbled into water (sterilizing it in the process) which can then be topically instilled or applied, or for longer-lasting benefits, into a lipid solution such as olive or other oil and applied directly to the skin or wound.
The benefits listed above are effective in all routes of administration reviewed above.

If you’re having pain problems, please let us know so we can help!
From a variety of IV therapies to local injections–or pretty much any other problem you may be having–we’re terrible mind readers–you need to let us know what’s going on so we can help speed your recovery!