07/12/2019
Mass spectrometry has become a paramount tool in biological, biomedical and clinical research to identify and quantify compounds within biological systems. Applications allow measurement of a wide range of endogenous biomolecules including peptides (peptidomics), proteins (proteomics), primary and secondary metabolites (metabolomics), lipids (lipidomics), nucleic acids, and carbohydrates (glycomics) from samples ranging single cells, fractionated organelles, cell lines, tissues or biofluids. This can be done in a “targeted” hypothesis driven manner or by an “untargeted” hypothesis generating approach. Exogenous compounds such as drugs and other xenobiotics can also be measured, often in the context of addressing preclinical or clinical questions in biodistribution, pharmacokinetics, and drug metabolism. In most cases, robust accurate and repeatable quantitative analyses are enabled and achieved through the use of stable-isotope labeling techniques. The UMMS Mass Spectrometry Facility provides a broad range of analytical assays that cover quantitative proteomics, protein analysis, metabolomics, lipidomics and mass spectrometry (tissue) imaging. The Facility supports seven mass spectrometry platforms for data acquisition and has extensive resources for sample preparation, data analysis, and informatics. The diverse expertise and experience among the Facility director and staff are leveraged to meet the needs of the internal collaborators and investigators at UMass, as well as other academic and industrial partners.
Check out the equipment that makes all this research possible from Mass. Spec. here --> www.umassmed.edu/MSF
The University of Massachusetts Medical School Mass Spectrometry Facility is a core resource offering state-of-the-art mass spectrometry for proteomics, metabolomics and mass spectrometry imaging.