02/24/2026
“GLP-1 stopped working in my 40s.”
And no… it’s not always because you need a higher dose.
Here’s what’s actually happening 👇
In your 40s:
• Progesterone drops first
• Estrogen starts fluctuating wildly
• Cortisol becomes more reactive
• Insulin sensitivity changes
So what used to work… stops working.
You increase the dose.
You eat less.
You work out more.
And the scale barely moves.
Because the issue isn’t appetite anymore.
It’s hormones.
When estrogen declines:
→ Fat distribution shifts to the abdomen
→ Muscle mass drops
→ Metabolic flexibility worsens
When progesterone drops:
→ Sleep worsens
→ Cortisol rises
→ Fat loss slows
If you don’t address the hormonal layer, GLP-1 becomes a band-aid instead of a strategy.
This is why some women thrive on GLP-1 in their 30s…
And struggle in their 40s.
The fix isn’t always “more medication.”
It’s:
✔ Hormone evaluation
✔ Muscle preservation
✔ Protein optimization
✔ Nervous system regulation
✔ Strategic dosing — not automatic increases
If your GLP-1 suddenly stopped working, it may not be the drug.
It may be your hormones.
👉 Have you noticed your results change after 40?
👇 Comment YES if this hit home