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Prof Dr James G Krueger, The Rockefeller University 1230 York Avenue New York, York, NY (2025)

07/23/2025

💖 Mood & Weight: The Power of Your Emotional World 💖
Hello everyone, I’m Dr. Tessa Langford .
Today, I want to talk about an often-overlooked yet critical factor in weight management—the connection between mood and weight.
😔 How Does Your Mood Affect Your Weight?
🍫 Emotional Eating
When we feel stressed, anxious, or down, we often turn to food for comfort—especially high-sugar, high-fat snacks. This can easily lead to excessive calorie intake.
🔄 Hormonal Changes
Negative emotions can disrupt hormone balance. For example, they may increase levels of ghrelin (the hunger hormone) while decreasing leptin (the satiety hormone), making us feel hungrier than usual.
⚡ Slowed Metabolism
Chronic stress and negative emotions may slow down your metabolism, making it easier for your body to store fat.
😴 Poor Sleep Quality
Low mood often disrupts sleep, and inadequate sleep further disturbs hormone regulation—creating a vicious cycle.
🌈 How to Boost Your Mood to Support Weight Management
🧘‍♀️ Practice Emotional Regulation
Take a few minutes each day for meditation or deep breathing. These simple techniques can help calm your mind and ease emotional tension.
👫 Stay Socially Connected
Talk to friends or family members. Sharing your feelings and seeking emotional support can make a big difference.
🏃‍♀️ Exercise Regularly
Physical activity not only burns calories but also elevates mood and reduces stress levels naturally.
💤 Prioritize Quality Sleep
Good sleep is essential for emotional balance and metabolic health. Aim for 7–9 hours of restful sleep each night.
Improving your mood doesn’t just make you feel better—it plays a powerful role in supporting sustainable weight management.
Remember, health isn’t just about a number on the scale—it’s about your overall quality of life and inner well-being.

05/28/2025

The Hidden Dangers of Excess Fat Accumulation
Excess fat—particularly visceral fat, which surrounds internal organs—is not just a cosmetic concern. It significantly elevates the risk of chronic diseases. Here’s how fat accumulation impacts overall health:
🫀 Cardiovascular Risks
Hypertension: Abdominal fat increases cardiac workload, raising blood pressure—a key risk factor for heart disease and stroke.
Coronary Artery Disease: Visceral fat promotes atherosclerosis (arterial thickening and narrowing), increasing the likelihood of heart attacks and other cardiovascular events.
🍬 Blood Sugar and Diabetes
Type 2 Diabetes: Abdominal fat leads to insulin resistance, making blood sugar regulation difficult and significantly raising the risk of type 2 diabetes.
🩸 Cholesterol and Liver Health
High Cholesterol: Excess fat can raise levels of LDL (“bad” cholesterol), contributing to plaque buildup and cardiovascular complications.
Non-Alcoholic Fatty Liver Disease (NAFLD): Visceral fat is a key driver of liver fat accumulation, potentially leading to inflammation, fibrosis, cirrhosis, or liver failure.
😴 Sleep and Respiratory Issues
Sleep Apnea: Fat deposits around the neck and upper airway heighten the risk of obstructive sleep apnea—a condition marked by disrupted breathing during sleep, linked to fatigue, cognitive issues, and heart disease.
🦴 Joint Pain and Mobility Challenges
Osteoarthritis: Excess weight puts additional strain on the knees, hips, and lower back, accelerating joint wear and increasing the risk of osteoarthritis.
🧴 Skin Aging and Elasticity
Loss of Collagen & Elasticity: Obesity can impair skin structure, resulting in wrinkles, sagging, and premature aging.
🎗 Increased Cancer Risk
Obesity is associated with a higher risk of cancers such as breast, colorectal, and endometrial cancer. Fat tissue influences hormone levels, which can affect tumor growth.
🫛 Gallstones and Digestive Problems
Gallstones: Elevated cholesterol and fat levels increase the risk of gallstone formation, potentially causing severe digestive issues that may require medical intervention.
🧠 Mental Health and Hormonal Imbalance
Depression and Anxiety: Obesity is often linked to low self-esteem, emotional distress, and a higher risk of mood disorders.
Hormonal Imbalances: Visceral fat can raise levels of cortisol (stress hormone) and estrogen, affecting metabolism, immunity, and reproductive health.
🔹 Key Takeaways:
✅ Visceral fat is a major risk factor for heart disease, diabetes, and metabolic disorders.
✅ It also contributes to poor sleep, joint pain, skin aging, and mental health challenges.

05/28/2025

What is Lymphatic Obstruction? Associated Health Risks
Lymphatic obstruction is a common health issue that can lead to the accumulation of toxins in the body, triggering a cascade of adverse effects. One major consequence is the buildup of body fat and fluid retention. When lymphatic flow is disrupted, toxins are not effectively cleared from the tissues, impairing cellular function, slowing metabolism, and increasing the risk of weight gain and edema.

05/28/2025

What is Lymphedema? Causes and Classification
Lymphedema is a condition characterized by the accumulation of lymphatic fluid in local tissues, resulting in swelling due to impaired lymphatic drainage. It can affect any part of the body, although it most commonly occurs in the arms, legs, or face. The etiology is generally classified into two main categories: primary and secondary lymphedema.
Primary Lymphedema is typically caused by congenital abnormalities in the lymphatic system and is often hereditary. Potential causes include:
Genetic Defects: Some individuals are born with underdeveloped lymphatic vessels, leading to impaired drainage. This type of lymphedema can present at birth or during childhood.
Lymphedema-Distichiasis Syndrome: A rare genetic disorder characterized by the presence of double rows of eyelashes (distichiasis) in conjunction with lymphedema.
Secondary Lymphedema (Acquired) is the result of external factors that block normal lymphatic flow. Common causes include:
Surgical Intervention: Cancer treatments may require removal of lymph nodes or lymphatic vessels, which can disrupt lymph drainage and lead to swelling. This is commonly seen in treatments for breast, prostate, or uterine cancer.
Radiation Therapy: Radiation can damage or scar lymph nodes and vessels, impairing lymphatic circulation and causing lymphedema.
Infections: Severe infections such as schistosomiasis or filariasis may cause lymph node inflammation or damage, compromising lymphatic function.
Trauma or Postoperative Complications: Injuries like burns or surgical incisions can damage lymphatic vessels, leading to localized swelling.
Chronic Diseases: Conditions such as heart failure, cirrhosis, or kidney disease can cause generalized fluid retention and may trigger or worsen lymphedema.
Obesity: Severe obesity increases the risk of lymphedema, as excess adipose tissue can compress lymphatic vessels and obstruct flow.
Inflammatory and Autoimmune Disorders: Chronic inflammatory conditions such as rheumatoid arthritis and systemic lupus erythematosus can disrupt lymphatic circulation and elevate the risk of edema.

05/28/2025

Patient Encounter and Weight Management Strategy
Today, I had the opportunity to meet Jane Smith, a woman in her fifties who has been struggling with multiple obesity-related health conditions. Due to her excess weight, Jane experiences joint pain, shortness of breath, and elevated blood sugar levels, which have increasingly hindered her ability to carry out daily activities. She often feels physically burdened and lacks the motivation for regular physical activity.
Jane expressed a strong desire to improve her symptoms through lifestyle modifications and a scientifically supported weight loss program, aiming to restore her health and quality of life. Together, we are working on a personalized weight management plan to help her achieve these goals and regain vitality and confidence.
Through my work with the NHS, I have encountered numerous patients with obesity and have come to understand the complex underlying factors and associated health risks. Many individuals, like Jane, face a combination of joint issues, metabolic dysfunction, and psychological distress that are interrelated and make it challenging to address the root causes of obesity. This experience has made it clear that conventional weight loss approaches may not fully resolve the multifaceted symptoms and complications.
This realization led me to consider developing a solution that integrates modern medicine with biotechnology—one that offers effective weight loss while simultaneously addressing obesity-related health concerns. It has inspired my ongoing research into innovative, science-backed solutions to provide patients with safe, effective treatment options that improve their overall health and well-being.

05/28/2025

Currently, I am applying the same out-of-the-box thinking to the Milstein Medical Research Program, which has an initial research focus on melanoma. Metastatic melanoma is the equivalent of a death sentence, killing one person every hour in the United States. As the ozone layer depletes, the threat of melanoma grows. The best hope for curing melanoma lies in understanding the initial steps of the metastatic process and blocking them. My research is carrying out exactly that enterprise. Our team is using advanced genetic methods and imaging techniques to study how “melanocyte” skin cells become malignant tumors. In this way, our work will reveal how their genetic and structural changes are interrelated in the later stages of the disease. The information gained from these experiments will help develop more accurate diagnostic techniques and more effective treatments.

05/28/2025

My research team focuses on human skin inflammation and autoimmune mechanisms. Our research is based on “lab-to-clinic” science, combining clinical studies of novel medical therapies with laboratory studies of relevant immunopathogenic mechanisms in human cells and tissues. The lab conducts clinical studies in patients with common psoriasis at Rockefeller University Hospital. We treat patients with a variety of engineered immune molecules to restore normal immune responses. By combining novel immune-directed therapies with large-scale gene expression studies, an approach known as pharmacogenetics, the researchers work to unravel the molecular pathways that lead to disease-causing inflammation and regulate normal human immune responses.

05/28/2025

historic moment！！！

Prof Dr James G Krueger

07/23/2025

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