Nuclear Medicine imaging and Theranostics

29/11/2025

Why lytic lesions are HOT on FDG PET image?
Read and share.
Nuclear Medicine imaging and Theranostics

29/11/2025

Direct vs indirect effects of radiation.
Direct effect directly damages DNA, while as indirect effect involves the formation of free radicals. Free radicals being unstable Damages the DNA.

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29/11/2025

Your diagnosis


fans Nuclear Medicine imaging and Theranostics Dlamini Hlubi Lomuhle Kareem Khan Moiz Ud Din Vivek Paudyal ايمن حماد Joana Rosas Karima Teboul Wajahat Padder Paul Czaja Robert B. Vargas Wåñî Shåmêem Saad A. Mahmood Lawmtea Ralte

29/11/2025

Lytic vs Blastic Bone Lesions — Nuclear Medicine Perspective

What Are Lytic Lesions?

Lytic = bone destruction
Caused by osteoclast overactivity → bone is broken down faster than it’s rebuilt.
Imaging Features
•Bone Scan (99mTc-MDP):
🔸 Can be cold, normal, or mildly active
🔸 Low osteoblastic activity → may be missed
•PET/CT (FDG):
🔸 Often high FDG uptake
🔸 Better for myeloma, RCC, thyroid, lung

Key Point:
Lytic lesions = poor visibility on bone scan, excellent on FDG PET.

What Are Blastic Lesions?
Blastic = bone formation / sclerosis
Caused by osteoblast overactivity → new bone is deposited.

Imaging Features
•Bone Scan (99mTc-MDP):
🔸 Very HOT
🔸 Excellent sensitivity
🔸 Shows extent of disease well
•PET/CT (FDG):
🔸 Can be low or variable FDG uptake
🔸 Better detected on PSMA PET and NaF PET

Key Point:
Blastic lesions = HOT on bone scan, excellent on PSMA / NaF PET.

28/11/2025

Iodine -131 administration.
High dose therapy for residual thyroid tissue in case of Ca thyroid patients.

28/11/2025

Dynamics of renal(DTPA)scan.
With normal Renogram.
Nuclear Medicine imaging and Theranostics

28/11/2025

That radiopharmaceutical feeling hits different 😂🔥

28/11/2025

Today’s Radioactive ☢️ waste.
Time to dispose off.

28/11/2025

Hyperfunctioning thyroid gland.
GRAVES DISEASE.
Nuclear Medicine imaging and Theranostics

28/11/2025

27/11/2025

PET–CT Artifacts You Must Know!

These common artifacts can mimic disease—or hide it.
Every Nuclear Medicine professional should recognize them.
1. Respiratory Misregistration

PET and CT are taken in different breathing phases → liver dome & lung bases appear mismatched.
Result: False lung hotspots or missing lesions.
2. Brown Fat Uptake

Symmetrical FDG uptake in supraclavicular and paraspinal regions.
Pitfall: Misinterpreted as nodal metastasis.
3. Bowel Uptake

Physiological FDG uptake varies → can simulate peritoneal or pelvic lesions.
Tip: Check for peristaltic patterns on CT.
4. Metallic Implants / Prosthesis

Cause CT streaks → wrong attenuation correction → false hotspots.
Fix: View non-attenuation corrected (NAC) images.
5. Motion Artifacts

Patient movement (especially arms/head) distorts PET lines of response.
Result: Blurred lesions or artificial streaks.
6. Injection Site Uptake / Lymphatic Spread

FDG pooling in arm or axilla → misread as pathological nodes.
Tip: Always check injection arm first.
7. High Blood Glucose Effects

Reduces FDG tumor uptake → false-negative scans.
8. Urinary Tracer Activity

Ureteral hotspots mimic abdominal/pelvic metastases.

Quick Rule:

Always compare AC (attenuation-corrected) with NAC (non-corrected) images
→ If the hotspot disappears on NAC → artifact
→ If persists → real uptake

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27/11/2025

Correct answer with explanation will be updated tomorrow same timing.
Nuclear Medicine imaging and Theranostics