01/30/2026
Before 1937, cannabis tinctures were not fringe medicine or counterculture remedies. They were mainstream pharmaceuticals, used daily by physicians to treat arthritis pain, inflammation, sleep disruption, and, at the time, what doctors called rheumatic disease.
In the late 1800s and early 1900s, cannabis tinctures were listed in the United States Pharmacopeia and the British Pharmacopeia. That matters because inclusion meant standardized preparation, dosing guidance, and accepted medical use. These tinctures were alcohol-based extracts of the cannabis plant, designed for oral use, easy absorption, and consistent effects. Doctors trusted them because they worked and because they were gentler on the stomach than many other options available at the time.
Arthritis patients were among the most common recipients. Long before we understood the ECS, our Master Regulator, clinicians observed that cannabis tinctures reduced joint pain, stiffness, and swelling while also improving sleep. That combination mattered. Pain relief without heavy sedation and improved rest without respiratory suppression were rare in that era.
Major pharmaceutical companies openly sold these products. Eli Lilly, Parke-Davis, Squibb, and Merck all produced cannabis-based medicines. These were not homemade remedies. They were labeled, dosed, and prescribed. Sir William Osler, often called the father of modern medicine, referenced cannabis preparations as effective for pain and muscle spasm. This was clinical observation guiding practice, not ideology.
What made tinctures especially effective for arthritis was their systemic action. When taken orally, cannabinoids circulate throughout the body, interacting with inflammatory pathways, nervous system signaling, and immune tone. Today, we will explain this through endocannabinoid signaling, cytokine modulation, and neural feedback loops. Back then, doctors simply noted that patients moved better, slept longer, and relied less on opiates.
All of that changed in 1937.
The Ma*****na Tax Act did not ban cannabis outright, but it made medical use legally dangerous and financially impossible. Doctors faced paperwork, scrutiny, and criminal risk. Pharmaceutical companies walked away. Within a few years, cannabis was removed from the Pharmacopeia, not because it failed patients, but because politics replaced medicine.
Arthritis care shifted toward aspirin, then steroids, then synthetic anti-inflammatories, and eventually long-term opioid use. Each step moved further away from whole-system balance and closer to symptom suppression.
When we talk today about rediscovering cannabis tinctures for arthritis, this is not new medicine. It is a restorative medicine. The plant never stopped working. We simply stopped listening to the patients who were already getting relief.
-Mike Robinson, The Researcher OG