William Makis McGill Medicine

William Makis McGill Medicine Radiologist, Oncologist, Cancer Researcher, Author of 100+ publications. Top Substack Author. makismd.substack.com send me an email on Info@makiswn.com

💊🦠How does FBZ "switch off" cancer? 6 key mechanismsFBZ is not an ordinary drug – preclinical studies show that it attac...
17/03/2026

💊🦠How does FBZ "switch off" cancer? 6 key mechanisms

FBZ is not an ordinary drug – preclinical studies show that it attacks cancer cells on multiple levels, which scientists call a "multimodal attack."

Here's how it works:

➡️1. Disintegration of the cellular "scaffold" (Microtubule Destabilization)
Cancer cells divide very rapidly. To do this, they need microtubules small tubes that act as a framework and a highway for transport within the cell.

✅FBZ works by: Binding to tubulin and blocking its structure.

✅Effect: The cancer cell cannot divide, becomes "frozen" in the division process (mitotic arrest), and ultimately dies (apoptosis). This mechanism is similar to that of powerful chemotherapeutic drugs, but often with lower toxicity to the body.

➡️2. Activation of the "gene guardian" (p53 protein)
The p53 protein is our body's natural defender, detecting DNA damage and instructing the defective cell to commit su***de. In many cancers, p53 is "dormant," allowing the cancer to grow unpunished.

✅FBZ Action: Stimulates p53 protein activity.

✅Effect: Restores the cell's ability to recognize its own errors and initiate the natural process of eliminating the tumor.

➡️3. Blocking "waste disposal" (proteasome inhibition)
Cancer cells produce a multitude of defective proteins, which they must dispose of through proteasomes (a type of cellular recycling) to survive.

✅FBZ Action: Disrupts the functioning of these "scavengers."
✅Effect: The cancer cell becomes inundated with its own protein waste, leading to its dysfunction and inhibition of tumor growth.

➡️4. Cutting off the fuel supply (Metabolic disorders)
Cancer is an "energy-hungry monster." It requires enormous amounts of glucose (sugar) and glutamine to fuel its rapid growth.

✅FBZ Action: Inhibits glucose uptake by cancer cells.

✅Effect: Cancer is literally starved. Without energy, it loses its ability to aggressively multiply.

➡️5. Blocking the formation of "pipelines" (Anti-angiogenesis)
To grow, a tumor forces the body to build new blood vessels that supply it with oxygen and nutrients.

✅FBZ Action: Limits the formation of these vessels.

✅Effect: The tumor cannot grow beyond a certain size because it has no "supply" source.

➡️6. Attacking the "roots" of cancer (Cancer stem cells)
This is the most difficult part of the fight. Classic chemotherapy often kills the "leaves" (normal cancer cells) but leaves the "roots" (stem cells) from which the cancer grows back.

✅How FBZ works: Studies suggest that fenbendazole can eliminate the most resistant cancer-initiating cells.

✅Effect: Reduces the risk of relapse and metastasis by attacking the very source of the disease.

Why is this groundbreaking?

Most cancer drugs focus on one of these points. FBZ seems to combine them all in a single molecule. This multi-pronged approach may explain the spectacular cases of remission in patients for whom conventional medicine had given up hope. you’re tired of feeling unwell and want to get back to your old self again, comment YES below. Let’s take the first step together. 👇👇🙏

BREAKING NEWS: Helping Cancer patients is now ILLEGAL in Canada, as Alberta Premier Danielle Smith punishes over 9000 Ca...
13/03/2026

BREAKING NEWS: Helping Cancer patients is now ILLEGAL in Canada, as Alberta Premier Danielle Smith punishes over 9000 Cancer patients for exercising their "Right to Try" with IVM

My Cancer work in Canada is officially done.
I'm moving to Florida and will work there. 🙏

Helping Cancer patients is now illegal in Canada.
Health Coaching of Cancer patients is now illegal.
Naturopathy is now illegal.
Using IVM and repurposed drugs is now illegal.
Doing podcasts and videos on Health is now illegal.

All punishable by up to 2 years imprisonment.

Canadians have no idea what has just transpired and what Canada has recently turned into.

The actions of Canadian authorities (pictured below, including far left extremist woke bureaucrats of the Alberta College of Physicians and Surgeons) amount to attempted murder of Cancer patients who wanted cutting edge options for their disease.

Canadians, your options are all GONE.

Please STOP asking me for help at this point.

You could have and should have stopped the Canadian authorities from doing any of this.
There were plenty of opportunities to do so.
Now it's too late.

Of course, Premier Danielle Smith's Alberta government can stop cancer patients from being harmed and reverse all of these actions within 24 hours. But they won't. They intend to kill every last Cancer patient instead.

We are documenting these deaths as they happen.

I've done all I could here, in Canada.
I've gone above and beyond.

When my Florida Cancer Clinic opens, look for me then. It will be BUSY💪

Good luck everyone! God bless 🙏

09/03/2026
BREAKING NEWS: Canadian authorities have issued extreme threats to my family's physical safety and well being.The nature...
08/03/2026

BREAKING NEWS: Canadian authorities have issued extreme threats to my family's physical safety and well being.

The nature of these threats is unprecedented in Canadian history. This is no longer the Canada my family fled to from Communism, and the Canada I grew up in and loved.

Please pray for my family. 🙏

05/03/2026

HPV Vaccine was the deadliest vaccine before the COVID-19 Vaccine genetic junk came along

Premature Ovarian Failure
Neurological Injuries
Sudden Death

Your ignorance of the topic is astounding

Read some VAERS Reports and S**U

A Breakthrough in Oncology? Fenbendazole Under the Microscope – Analysis of New Clinical CasesAlthough preclinical studi...
04/03/2026

A Breakthrough in Oncology? Fenbendazole Under the Microscope – Analysis of New Clinical Cases

Although preclinical studies have long suggested that fenbendazole (an antiparasitic drug) can destroy cancer cells by blocking their metabolism and division, hard evidence of its effectiveness in humans has been lacking. However, this situation is changing. The latest case series published by Dr. William Makis in the prestigious Case Reports in Oncology sheds new light on this substance's potential in treating the most advanced stages of cancer.

Here are the stories of three patients with stage IV cancer who decided to incorporate fenbendazole into their therapy, achieving astonishing results.

➡️1. Spectacular Reversal of Metastases in Breast Cancer
An 83-year-old patient was struggling with metastatic breast cancer (ER/PR-positive, HER2-negative). The disease had already spread to the liver, lungs, and spine. Standard prognosis for this condition is usually very poor.

✅Therapy:
The patient took 222 mg of fenbendazole daily, combined with an estrogen blocker and vitamin D supplementation. She underwent only a short course of radiotherapy for her spine, avoiding aggressive chemotherapy.

✅Results:
After just eight months, tumor markers returned to normal, and a PET scan confirmed the complete absence of active cancerous lesions. The patient has been relapse-free for nearly three years, continuing to take the medication without any side effects.

➡️2. Follow-up of advanced prostate cancer

A 75-year-old man was battling recurrent prostate cancer that had metastasized to the bones (spine, pelvis, humerus) and lymph nodes.

✅Treatment:
In addition to standard hormonal therapy, the patient implemented an intensive supplementation protocol (berberine, curcumin, artemisinin, melatonin) and fenbendazole at a dose of 222–444 mg daily.

✅Results:
Tests showed regression of metastases in the bones and lymph nodes. PSA levels (a prostate cancer marker) dropped to undetectable levels and have remained at this level for over two years. The patient is in almost complete remission.

➡️3. Hope in Melanoma (Supplementary Case)
The third case involved a patient with metastatic melanoma who, after starting fenbendazole, experienced sustained inhibition of disease progression, confirming the universality of this drug's mechanism of action on various types of cancer tissue.

What does this mean for the future of treatment?

These stories are not just "anecdotes," but thoroughly documented medical cases that suggest that:
Synergy is key: Fenbendazole appears to enhance the effects of standard therapies (hormonal and radiotherapy).

✅Safety: Even with long-term use, patients tolerated the drug well.

Potential for a "recycled drug": Using known substances may be a faster path to saving lives than waiting a decade for new drugs. Despite these optimistic reports, the scientific community emphasizes that fenbendazole is not yet a medical standard. Each case requires individual consultation, and the above data should serve as an impetus for initiating extensive clinical trials.

Most people know Iver as an anti-parasitic medicine, but very few realize that science has uncovered powerful anticancer...
03/03/2026

Most people know Iver as an anti-parasitic medicine, but very few realize that science has uncovered powerful anticancer effects that work on some of the body’s deepest cellular levels.

When studied under the microscope, Ivermctin has been shown to interfere with the very channels and fuel sources cancer depends on to survive.

1. Glutamate-Gated Chloride Channel Activation

Cancer cells maintain electrical and chemical balance through channels in their membranes.

Iver binds to these glutamate-gated chloride channels, forcing an influx of chloride ions that causes the cell to lose control of its voltage balance.

This sudden shift triggers oxidative stress, mitochondrial collapse, and apoptosis (programmed cell death).

In simple terms: it opens the floodgates and short-circuits cancer cells from the inside out.

2. Starving Cancer’s Fuel Supply

Cancer cells crave glutamine—their main energy source.

Iver helps block glutamine uptake and metabolism, effectively starving tumors while leaving healthy cells unharmed.

This aligns with metabolic therapies that cut off both glucose and glutamine, forcing cancer to burn itself out.

3. Blocking Oncogenic Pathways (PAK1 + WNT/β-Catenin)

Iver has been shown to inhibit PAK1, a protein that promotes tumor growth, and to suppress WNT/β-catenin, which fuels cancer stem-cell renewal.

By quieting these “grow” signals, Iver helps shut down the cancer’s command center.

4. Triggering Apoptosis & Autophagy

Inside the mitochondria, Iver activates caspase pathways that tell damaged cells to self-destruct.

It also promotes autophagy, the body’s natural clean-up process that removes malfunctioning cells—another layer of immune support in the cancer fight.

5. Reducing Tumor Spread and Inflammation

Iver blocks P2X4 and P2X7 purinergic receptors, which are involved in tumor invasion and inflammatory signaling.

This can reduce metastasis and calm the inflammatory terrain that cancer thrives in.

6. Cutting Off Tumor Blood Supply

Iver helps lower VEGF, the molecule that tells the body to grow new blood vessels for a tumor.

Without that supply line, cancer cells lose their oxygen and nutrients.

Summary of Effects

Mechanism and Actions

Glutamate-gated chloride channels/ Triggers cancer-cell death

Glutamine metabolism blockade/ Starves tumor of energy

PAK1 & WNT/β-Catenin inhibition/ Shuts down growth signals

Mitochondrial apoptosis/ Destroys cancer cells from within

P2X4/P2X7 inhibition/ Reduces spread & inflammation

Anti-angiogenesis / Cuts off blood supply to tumors

In short: Iver works on multiple levels—disrupting electrical signaling, starving cancer’s fuel, silencing its growth pathways, and supporting the body’s natural cleanup systems.

When combined with a clean, KMT diet, detoxification, and immune support, it becomes a powerful ally in the body’s healing process.

BREAKING NEWS: Give a Friend or Family member with CANCER easy access to crucial information!Although my Sub.stack has h...
02/03/2026

BREAKING NEWS: Give a Friend or Family member with CANCER easy access to crucial information!

Although my Sub.stack has hit #2 in the world, from reading thousands of emails I realize most people still don't have access to life saving information.

Many people still don't know what Sub.stack is or how to access the wealth of information on IVM, FBZ and MBZ.

Give them a gift! 😃

Access to 2400+ articles, testimonials, videos on cutting edge Cancer Care 💪

I run the world's largest IVM Cancer Clinic and over 8600+ Cancer patients are benefiting but so many still don't know! 🙏

So many people come to me in pain, with questions, with symptoms that doctors can’t explain or resolve. They want to fee...
01/03/2026

So many people come to me in pain, with questions, with symptoms that doctors can’t explain or resolve. They want to feel better. They want to heal. But they’re scared.
Scared to try something different.
Scared to trust again after being disappointed.
Scared that nothing will work.
And I don’t blame them. After years of being handed medications, dismissals, or vague answers, it’s hard to believe healing is possible especially through natural means. But I’m here to tell you something simple and powerful:
Healing is not a miracle. It’s the result of working with the body, not against it.
And that’s exactly what my protocol is designed to do.
I’ve spent over 15 years helping people reverse illness using natural herbs, roots, and a deep understanding of how the body heals when given the right tools. This is not guesswork. It’s not a quick fix. It’s a step-by-step path toward restoring balance gently, safely, and powerfully.
I’ve helped people recover from conditions doctors said were “incurable.” Not because I have magic, but because nature has answers and I know how to work with it.
So if you’re reading this and feel a little curious but also a little scared, let me speak to that part of you:
You don’t have to dive in blindly. You just have to take one step.
Start a conversation. Ask your questions. I’ll listen.
There is a path for you. It’s real. And I will walk it with you.
Don’t let fear steal your chance at healing.
Your body wants to get well. And together, we can help it do just that. Kindly states your health issues or send me a direct message to get started.

After thoroughly examining over 35 clinical studies and analyzing more than 90 significant findings, I’ve developed a po...
26/02/2026

After thoroughly examining over 35 clinical studies and analyzing more than 90 significant findings, I’ve developed a potent 🪱 Parasite cleanse Protocol that centers around FBZ, ALBZ, MBZ, and IVM

Are you interested in accessing the complete Parasite cleanse Protocol Kit? Simply send me a direct message.

25/02/2026

BREAKING NEWS: First-in-the-World IVM, MBZ and FBZ Protocol in Cancer has been peer-reviewed and published.

The future of Cancer Treatment starts NOW.

My thanks to lead authors Ilyes Baghli and Pierrick Martinez for their incredible inspired work, FLCCC’s Dr.Paul Marik for his extensive work on repurposed drugs and every co-author who worked hard to bring this paper to life.

I hope that this peer-reviewed paper lays the groundwork for a brand new future for Cancer Treatment.

Many of you know that I have been helping thousands of Cancer patients with high dose IVM, MBZ, and FBZ.

We are already starting to see incredible successes with these repurposed drugs.

Mainstream Oncology collapsed after the rollout of contaminated COVID-19 mRNA Vaccines.

Most Oncologists abandoned their Hippocratic Oath, gave contaminated mRNA Vaccines to all their cancer patients and took the mRNA jabs themselves.

Some Oncologists have now developed mRNA Induced Cardiac arrests, blood clots and Turbo Cancer. Others have already died suddenly.

These Oncologists buried their heads in the sand and abandoned everything that it takes to be a good competent doctor.

However, there are doctors who are blazing a new path into the future. See you there! 😃

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