04/04/2025
🚫 Gingipains and Their Connection to Alzheimer’s
A study published in Science Advances found evidence of gingipains in the brains of people with Alzheimer’s. These toxins can:
✅ Degrade essential proteins in neurons.
✅ Induce an inflammatory response that accelerates neurodegeneration.
✅ Promote the accumulation of beta-amyloid, a key protein in Alzheimer’s disease.
Furthermore, researchers are exploring gingipain inhibitors as potential treatments to slow disease progression.
🚫 Gingipains and Their Impact on Overall Health
Beyond Alzheimer’s, gingipains may also contribute to other systemic diseases, such as:
⚠️ Diabetes: Chronic inflammation from periodontitis can make blood sugar levels harder to control.
⚠️ Cardiovascular diseases: P. gingivalis has been found in atherosclerotic plaques.
⚠️ Rheumatoid arthritis: A link has been identified between periodontal disease and autoimmune conditions.
🚫 How to Prevent Gingipains-Related Damage?
📌 Maintain a strict oral hygiene routine (brushing, flossing, and antibacterial mouthwash).
📌 Visit the dentist regularly to detect early signs of periodontitis.
📌 Follow an anti-inflammatory diet rich in antioxidants and omega-3.
📌 Avoid smoking, which exacerbates periodontal inflammation.
