Gknowmix - Genetic knowledge integration

Gknowmix - Genetic knowledge integration Gknowmix develops tests that help clinicians to prevent or treat chronic diseases with a genetic com

Sevice delivery is driven by cutting-edge research performed in the pathology Research Facility of the University of Stellenbosch.

Thank you Chantelle Jennifer Scott  for your insightful presentation at our Post COVID-19 Symposium on Saturday. The nex...
28/07/2025

Thank you Chantelle Jennifer Scott for your insightful presentation at our Post COVID-19 Symposium on Saturday. The next step is to implement the novel genetic counselling model with the help of a multidisciplinary team including Janine Forbes - Cronje. Her new company Carepoint Genetics referred to by Prof Maritha Kotze at the closure of the symposium is an important outcome of the research performed. The aim is to increase access to point-of-care genotyping as a screening step to determine the need for extended genetic testing. This includes whole genome sequencing, if clinically indicated.

Taking a break after the Genomics Initiation Meeting on 19 December with Dr Phetole Mahasha joining online as our projec...
25/12/2024

Taking a break after the Genomics Initiation Meeting on 19 December with Dr Phetole Mahasha joining online as our project manager for the newly-funded SAMRC clinical implementation study. Wonderful Wonderful

A small portable real-time PCR machine forms the entry point for implementation of pathology-supported genetic testing p...
14/11/2024

A small portable real-time PCR machine forms the entry point for implementation of pathology-supported genetic testing presented at the congress today!

31/10/2024

Discover the Gknowmix Pathology-supported Genomics Testing platform, making proactive healthcare accessible to everyone!







Proud to announce that Gknowmix - Genetic knowledge integration - has been awarded a Strategic Health Innovation Partner...
18/10/2024

Proud to announce that Gknowmix - Genetic knowledge integration - has been awarded a Strategic Health Innovation Partnership grant in the Research Area Non-communicable diseases on 17 October 2024. The project entiled "Advancement of a pharmacogenetics platform for point-of-care POC) assay validation towards implementation of whole genome sequencing (WGS) in clinical practice" is supported by the SAMRC with funds received from the Department of Science and Innovation. The research translation team is committed to help further the cause of CANSA to increase health and equity in South Africa.

The Global Week for Action on NCDs (15 to 22 October) aims to unite the NCD (Non-Communicable Disease) movement each year under a specific theme, concentrating our combined efforts with the aim of reducing the NCD burden globally and increasing health and equality.

This year’s theme is centred on leadership and underscores the urgent need for global leaders to take bold action in addressing the burden of NCDs.

https://cansa.org.za/global-week-for-action-on-ncds-15-to-22-october-2024/

To raise awareness about the importance of early   detection in     please share this testimonial of a breast cancer sur...
13/10/2024

To raise awareness about the importance of early detection in please share this testimonial of a breast cancer survivor in Mauritius who has been referred by Dr Rika Pienaar in South Africa for the MammaPrint test offered by Gknowmix.

”It is Cancer” said the surgeon who had performed the Tru Cut biopsy. As I was processing the news, I realised that I wasn’t scared by the Cancer itself. I was feeling perfectly fine at the time. No pain, no discomfort whatsoever. The first question I typed into Google’s search tab was “Breast cancer: does everybody need chemo?”.

Frantic searches led to links, websites, patient support forums until amongst all the noise, I had the ‘aha!’ moment:

“If you decide to have the MammaPrint test, you and your doctor will consider a number of factors when deciding on whether to add chemotherapy to your treatment plan”. “Whether to add”, those precious three words meant that chemotherapy is not always necessary, and I hung onto this hope. As luck will have it, I also had the ‘right’ type of breast cancer for the MammaPrint test.

Post surgery, I went back to see the oncologist I was referred to after diagnosis. He did not seem to have all the details regarding MammaPrint but was adamant that this test would be a waste of my time and money because, in my case, avoiding the Big C was not an option.

According to his calculations, I had a 29% risk of relapse within 10 years, and on this basis, he drew a calendar for my chemotherapy. 6 rounds of chemo, followed by 30 rounds of radiation therapy. With resting time in between this forecast meant that I would be on the cancer wagon until February 2015.

I was mentally getting ready to undergo chemo, but I would only agree to it if it was necessary for me. Two weeks later, Dr Rika Pienaar, the referring oncologist for MammaPrint in Cape Town, announced the results I was hoping for: My MammaPrint test revealed a low risk of recurrence within the next 5 years and I could safely skip chemo, if I so wished.
I completed my last round of radiation therapy in South Africa exactly three months and three days after surgery.

There was no fight, no battle engaged on this journey. It was a smooth ride, I was fully functional throughout, and never once did I feel or look sick. In fact, most people had no idea I was being treated for cancer.

It pains me to know that to this day, too many women are being ‘subjected’ to chemotherapy for close to zero benefit. Back in 2014, the logistics to send my sample for MammaPrint testing from Mauritius was a challenge in itself, and I will be eternally grateful to Professor Maritha Kotze for her help in making this happen.
I am glad to see know that Mauritian patients will soon have an easier access to MammaPrint testing in order to make an informed choice regarding chemotherapy.

MammaPrint truly is the game-changer.

- Patient Nelly, diagnosed at 41 years old

Retirement function at Stellenbosch University where Emeritus Professor Maritha Kotze provided her vision for the integr...
12/10/2024

Retirement function at Stellenbosch University where Emeritus Professor Maritha Kotze provided her vision for the integration of genomics into clinical practice. research translation remains a focus area together with clinician scientists such as Prof Karin Baatjes, as one of her previous PhD students.

Thank you to everyone who joined yesterday to say goodbye with the retirement of Maritha Kotze from the NHLS at the end ...
28/06/2024

Thank you to everyone who joined yesterday to say goodbye with the retirement of Maritha Kotze from the NHLS at the end of this month! Starting a new day with THIS PRESENT and a big thank you to Stellenbosch University, Faculty of Medicine and Health Sciences for the appointment as Emeritus professor going forward! REFIRED!

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