15/06/2025
This is a complex but very insightful article about PCOS. PCOS is not only a hormonal disturbance, with often higher testosterone levels and lower progesterone due to irregular ovulation.
It is also
> changes in your DNA, where some genes are switched on or off via methylation
> changes in your brain - insulin resistance changes how your brain responds to food cues, making you want to eat high sugar and high fat meals
> changes in your gut microbiome, worsened by food choices, influencing your mood and metabolism
And this leads to changes in your metabolic profile that makes you prone to insulin resistance, obesity, high cholesterol, high blood pressure and heart disease (metabolic syndrome)
What stands out in this article:
> High fibre diet improves the beneficial bacteria in your gut (fruit, veg)
> Individualised exercise plan to focus on weight loss and muscle building
> Medical treatment for insulin resistance include metformin, inositol and GLP1
Babies born to mothers with PCOS are prone to childhood obesity, insulin resistance and the metabolic syndrome.
Key message: Any patient, but especially if you have PCOS, should focus on their health before they want to conceive. This means - being a normal weight, exercising, not smoking or using alcohol, eating a fibre rich diet.
If a PCOS patient is in optimal health before they get pregnant then
> Less inflammation
> Easier to get pregnant
> Less miscarriages
> Less gestational diabetes
> Less pre eclampsia, growth restriction, preterm birth
> Less long term effects on the health of the children born (obesity, insulin resistance, metabolic syndrome)
# PCOS
📝Hot Opinion by Dr. Tao Tao. et al from Shanghai Jiao Tong University School of Medicine:
"Polycystic O***y Syndrome: Challenges and Possible Solutions"
📩Full text: https://bit.ly/456Et0T