
06/08/2025
Ultrasound of the Uterus : Endometrium
Endometrial thickness is a commonly measured parameter on routine gynaecological ultrasound and MRI. The appearance, as well as the thickness of the endometrium, will depend on whether the patient is of reproductive age or postmenopausal and, if of reproductive age, at what point in the menstrual cycle they are examined.
Radiographic features
Ultrasound
The endometrium should be measured in the long axis or sagittal plane, ideally on transvaginal scanning, with the entirety of the endometrial lining through to the endocervical canal in view 10. The measurement is of the thickest echogenic area from one basal endometrial interface across the endometrial canal to the other basal surface. Care should be taken not to include hypoechoic myometrium or intrauterine fluid in this measurement.
The normal endometrium changes in appearance as well as in thickness throughout the menstrual cycle:
in the menstrual and early proliferative phase it is a thin, brightly echogenic stripe comprising of the basal layer; minimal fluid can be appreciated endovaginally within the endometrium in the menstrual phase
in the late proliferative phase it develops a trilaminar appearance: outer echogenic basal layer, middle hypoechoic functional layer, and an inner echogenic stripe at the central interface
in the secretory phase it is at its thickest, up to 16 mm 10, and becomes uniformly echogenic, as the functional layer becomes oedematous and isoechoic to the basal layer; there is through transmission and posterior acoustic enhancement noted
The postmenopausal endometrium should be smooth and homogeneous.
Normal range of endometrial thickness
The designation of normal limits of endometrial thickness rests on determining at which thickness the risk of endometrial carcinoma is significantly increased.
Whilst quantitative assessment is important, endometrial morphology and the presence of risk factors for endometrial malignancy should also be taken into account when deciding whether or not endometrial sampling is indicated.
Premenopausal
In premenopausal patients, there is significant variation at different stages of the menstrual cycle.
during menstruation: 2-4 mm 1,4
early proliferative phase (day 6-14): 5-7 mm
late proliferative / preovulatory phase: up to 11 mm
secretory phase: 7-16 mm
following dilatation and curettage or spontaneous abortion: