20/10/2025
The Vicious Cycle: How Chronic Stress Fuels Inflammation and Disease. Did you know that 75% to 90% of human disease is estimated to be related to stress and inflammation? This includes cardiovascular, metabolic, and neurodegenerative conditions. Hereβs the breakdown of the Vicious Cycle:
1. Chronic Stress: Keeps cortisol constantly high.
2. Glucocorticoid Receptor Resistance: Cells become resistant to cortisol's anti-inflammatory effects.
3. Inflammation Takes Over: Failure to downregulate inflammation leads to a damaging inflammatory state.
4. Gut-Brain Connection: Stress hormones damage the intestinal lining and disrupt gut microbiota, contributing to GI disorders and triggering immune responses. Functional Medicine recognizes that breaking this cycle requires addressing the inflammatory pathway and supporting the microbiome. Focus on managing chronic stress is paramount to reducing systemic inflammation.