17/02/2022
LEUKAEMIA
By Chipo James Mainda
Leukaemia is a malignant disease that is characterized by hyperplasia (rapid multiplication) of white blood cells and their precursors. It is a form of cancer in which the body produces too many abnormal white blood cells.
One of the function of bones is hematopoiesis (which is the process of production of blood cells which continues throughout life replacing aged cells). Normally, blood production occur in the bone marrow to a specific stem cell called hematopoietic stem cell. During blood production, hematopoietic stem cell give rise to two main blood precursors namely:
1. Myeloblastic linage
2. Lymphoblastic linage
The lymphoblastic linage will mature to form lymphocytes, which are white blood cells. This further will be divided to form B and T lymphocytes. On the other linage (myeloblastic linage), the myeloblastic precursors will mature into erythrocytes, thrombocytes, and leukocytes. In this linage, leukocytes will further be divided to form granulocytes and monocytes.
Once the various blood cells form, they leave the bone marrow and travel around the blood vessels to perform their various functions. Erythrocytes carry oxygen to all parts of the body, white blood cells fight invading foreign invaders, while thrombocytes are involved in the process of blood clotting.
The actual cause of leukaemia is unknown however, the predisposing factors may include;
* Exposure to radiations
* Exposure to chemicals such such benzene
* Some viruses
* Generics because it tends to occur in some families
* Chemotherapy.
These factors disturb the normal production of blood cells inside the bone marrow resulting in hyper production of the white blood cells only. Leukaemia has two effects on the body.
First, the white blood cells may not mature properly as they develop. They may lack the ability to kill microorganisms in the bloodstream. This defect seriously damages the immune system and the body loses its ability to fight infections. This will then lead to frequent infections, enlarged lymph nodes, fever etc
Secondly, so many white blood cells may form that they pack the bone marrow until there is not enough room for red blood cells and thrombocytes to develop. Without erythrocytes, the body's cells do not get enough oxygen, and the condition known as anaemia develops. Without thrombocytes, blood can not clot properly and simple injuries can lead to serious blood loss.