
29/09/2025
PULMONARY TUBERCULOSIS
By Chipo James Mainda
Pulmonary tuberculosis, is a chronic infectious disease of the respiratory system affecting the lungs, in which there is formation of tubercles/granulomas in the lungs, that is caused by mycobacterium tuberculosis, characterized by night sweats, dry or productive cough and fever.
Normally, during inhalation, air enters the lungs by travelling down the trachea. Then it continues to the bronchi and bronchioles and ends up in the alveoli. The alveoli are tiny air sacs surrounded by small blood vessels called capillaries, and this is where gaseous exchange takes place. Tuberculosis is an airborne disease transmitted by respiratory droplets.
When the mycobacterium gains access in succeptible condition, it'll reach the alveoli in the lungs where it'll multiply invading the lung tissue and trigger an immune response via inflammation. The mycobacterium bacilli will then be ingested by macrophages normally found in the lungs forming the classical tuberculous granuloma, which is a primary lesion. This usually remains small and commonly heals without becoming detectable.
The mycobacterium may further be contained inside the granulomas especially if the immunity is good, the body will wall off the infection. Although the bacilli remain alive for years. This is called primary tuberculosis. Basically, the patient will have no signs, no symptoms of the disease, but will have a calcified spot seen on X-ray, and some immunoglobulins may be isolated.
The lymphocytes will also be sensitized and in response will work together with the macrophages to surround and engulf the bacilli in the lungs. This acquired immunity usually inhibits further growth of the bacilli and further development of active infection.
If the immunity is not strong and can't handle the bacilli, the infection tends to be aggressive. The bacilli may spread from the lungs via the bloodstream or lymphatic system to other parts/organs of the body, including the meninges, bones, liver, kidneys etc. Other than that, necrosis of lung tissue occurs, producing a caseous (cheesy) substance composed of bacteria, pus and mucus. This is coughed up as sputum, leaving a cavity in the lung. If cavities erode the blood vessels, the patient will cough up blood. When healing occurs, there will be much scar tissue.
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