13/01/2026
DYSENTERY
By Chipo James Mainda
Dysentery is an acute or chronic inflammatory disorder of the gastrointestinal tract affecting the intestine, especially the colon, caused by the shigella bacteria and entamoeba histolytica protozoa, that results in severe diarrhea containing mucus and/or blood in f***s with fever, pain on passing stool, foul smelling stool and abdominal pain. Dysentery is transmitted via f***l oral route.
The gastrointestinal tract is made up of the alimentary canal, a tube running from the mouth to the a**s. Normally, digestion begins when food is taken into the mouth through the process called mastication. The food or water is then swallowed passing through the esophagus into the stomach. In the stomach, chemical digestion continues to breakdown large particles into smaller particles for easy absorption. From the stomach, food will be directed into the intestines for absorption of necessary nutrients, then unwanted substances will be removed from the body through the a**s.
Humans may get the infection by ingesting food or water contaminated by f***s from carriers of the bacteria.The spread of dysentery is more common in poor hygienic conditions.The ingested bacteria will pass the stomach acid barrier and multiply very rapidly in the intestines where they produce toxins.These toxins cause severe inflammation of the mucosal lining of the colon.The organism generally infects the epithelial cells of the terminal ileum and colon and multiplies inside them. In bacillary dysentery, the shigella enters the gastrointestinal tract and invades the large intestines causing inflammation of the mucosa layer.This will lead to ulceration and bleeding of the mucosa layer of the colon which will result in blood stained and mucoid stool. In the later stage, pus forms due to infection, and adjacent lymph nodes may be affected resulting into fever.
The pathophysiology for amoebic dysentery is similar to that of bacillary dysentery, but it does not usually cause ulcers in the intestines. Once the protozoa (entamoeba histolytica) is ingested, it will form cysts in the intestines and then enter the intestinal wall and intestinal mucosal through the mesenteric artery. Through the bloodstream, the protozoa will reach the liver causing total destruction of the liver thus causing hepato cellular necrosis and then liver abscess. It also affects the spleen and lungs as well as the brain and other organs as the protozoa spreads.