12/10/2025
Depression and anxiety are not personal flaws.
They are messages from our bodies and hearts that something important is missing.
For decades, we were told that depression is caused by a chemical imbalance in the brain — specifically, a shortage of serotonin. Yet research now shows this idea has little scientific basis. A major 2022 review published in Molecular Psychiatry by Professor Joanna Moncrieff and colleagues found no consistent evidence that low serotonin causes depression. Even the authors of early serotonin studies have since acknowledged that the theory was oversimplified and unsupported by data.
Despite record numbers of people in therapy and on medication, symptoms of depression and anxiety have tripled in recent years. Su***de rates continue to rise. Nearly one in six people feels lonely, and tens of millions live without access to meaningful mental-health care.
As .hari describes, we are facing a crisis of connection. Humans evolved for community, purpose, and belonging, but modern life often isolates us through digital overload, frantic work schedules, and fragile social ties. When our needs for intimacy, rest and meaning aren’t met, the nervous system protests: with panic, with numbness, with exhaustion.
That’s why therapy can help us understand and process our pain, but for many, it doesn’t fully resolve it. Because what we’re experiencing isn’t just a “brain disorder” it’s a whole-person response to disconnection, stress, and unmet emotional needs. Healing often begins not in suppressing symptoms, but in reconnecting, to ourselves, to others and to the things that give our lives meaning.