09/09/2023
【「柏金遜病」又關條「腸」事⁉】柏金遜病是全球第二常見的腦神經系統退化疾病，及早介入可減輕病徵對患者的影響。「快速眼動睡眠期行為障礙」（Rapid eye movement sleep behavior disorder，RBD，又稱「發夢期夢遊」）為柏金遜病先兆期常見的病徵，中大醫學院研究發現，RBD患者及其直系親屬會出現與柏金遜病患者類似的腸道微生態失衡，他們腸道內促進健康的細菌減少，促進炎症和破壞腸道屏障功能的細菌增多。
研究團隊指出，此發現揭示腸道微生態失衡是柏金遜病非常早期的風險因素，甚至早於RBD症狀的出現，因此藉着檢測腸道微生態，有望找出高風險演變為柏金遜病的個案，及早預防、介入及治療柏金遜及其他腦退化病。研究結果已刊載於國際頂尖科學期刊《自然通訊》（Nature Communications）。
詳情: https://bit.ly/3rnJlg0
研究全文: https://bit.ly/3rkDqs6
【How gut health links to Parkinson’s Disease⁉】Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Early intervention reduces symptoms’ impact on patients. A study conducted by CU Medicine discovered that patients with rapid eye movement sleep behaviour disorder (RBD), a sleep disorder common in patients at the prodromal stages of PD, suffer gut microbiome dysbiosis similar to that of PD patients. In addition, the research team found that similar changes in gut microbes have already emerged in first-degree relatives of RBD patients. Notably, the abundance of health-promoting bacteria is depleted in their gut, while pro-inflammatory bacteria that could potentially disrupt intestinal barrier integrity are enriched.
Study results revealed that gut microbiome dysbiosis is a risk factor at the very early stage of PD, even occurring before the onset of RBD. This sheds light on the identification of high-risk prodromal PD cases by gut microbiome screening, as well as paving the way for early intervention, prevention and treatment of PD and other neurodegenerative diseases by targeting gut microbiome features. Study details have been published in the leading international journal Nature Communications.
Details: https://bit.ly/43ieTkO
Full article of study: https://bit.ly/3rkDqs6
