05/05/2021
Headline: Multi-institution four-year liver cancer study recruiting 2000 high-risk patients for participation
The National Cancer Centre of Singapore launched a four-year liver cancer study and plans to recruit 2,000 high-risk patients with hepatocellular carcinoma (HCC) to find out how to more accurately diagnose early HCC and patients at risk for the condition. About 400 to 500 new cases of liver cancer are diagnosed in Singapore each year. Although early diagnosis can increase the chance of cure, only 20% of cases are detected at a stage when cure is possible. There are no confirmed biomarkers for the diagnosis, prediction and prognosis of HCC which would allow for early diagnosis.
Professor Pierce Chow, Principal Investigator of the study and Senior Consultant, Division of Surgery and Surgical Oncology, Singapore General Hospital (SGH) and NCCS pointed out that while patients may be asymptomatic at an early stage, liver cancer can proliferate very quickly.
The ELEGANCE study is recruiting patients between the ages of 50 and 90 at high risk of HCC, who have cirrhosis, hepatitis B or C, non-alcoholic fatty liver, or non-alcoholic steatohepatitis. Prof Chow elaborated on the three goals of the study: to test microRNA in the blood to diagnose HCC, develop an AI algorithm to predict the risk of an individual developing HCC and identify potential therapeutic targets in the metabolome and microbiome which can help prevent HCC and delay the progression of chronic liver disease.
Headline: Multi-institution four-year liver cancer study recruiting 2000 high-risk patients for participation
The National Cancer Centre of Singapore launched a four-year liver cancer study and plans to recruit 2,000 high-risk patients with hepatocellular carcinoma (HCC) to find out how to more accurately diagnose early HCC and patients at risk for the condition. About 400 to 500 new cases of liver cancer are diagnosed in Singapore each year. Although early diagnosis can increase the chance of cure, only 20% of cases are detected at a stage when cure is possible. There are no confirmed biomarkers for the diagnosis, prediction and prognosis of HCC which would allow for early diagnosis.
Professor Pierce Chow, Principal Investigator of the study and Senior Consultant, Division of Surgery and Surgical Oncology, Singapore General Hospital (SGH) and NCCS pointed out that while patients may be asymptomatic at an early stage, liver cancer can proliferate very quickly.
The ELEGANCE study is recruiting patients between the ages of 50 and 90 at high risk of HCC, who have cirrhosis, hepatitis B or C, non-alcoholic fatty liver, or non-alcoholic steatohepatitis. Prof Chow elaborated on the three goals of the study: to test microRNA in the blood to diagnose HCC, develop an AI algorithm to predict the risk of an individual developing HCC and identify potential therapeutic targets in the metabolome and microbiome which can help prevent HCC and delay the progression of chronic liver disease.
Read the article online: www.nccs.com.sg/news/research/multi-institution-four-year-liver-cancer-study-recruiting-2000-high-risk-patients-for-participation