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Polio has been detected in New York City wastewater, suggesting local circulation of the virus, health officials said Fr...
08/13/2022

Polio has been detected in New York City wastewater, suggesting local circulation of the virus, health officials said Friday.

New York State Health Commissioner Dr. Mary Bassett called the findings alarming. Bassett said local and federal health officials are aggressively assessing how far polio has spread in the city and in New York state.

“For every one case of paralytic polio identified, hundreds more may be undetected,” Bassett said. ”The best way to keep adults and children polio-free is through safe and effective immunization.”

Polio can result in permanent paralysis of the arms and legs and death in some cases. Health officials are calling on people who are not vaccinated to get their shots immediately.

Routine vaccinations among children have declined in New York City since 2019, which has increased the risk of outbreaks, according to health officials. About 14% of New York City children ages 6 months to 5 years old have not completed their vaccination series against polio, which means they are not fully protected against the virus.

Overall, 86% of children ages 5 and under in New York City have received three doses of the polio vaccine, according to health officials. But there are some neighborhoods in the city where less than 70% of children are up to date on their polio vaccines, which puts kids in these communities at risk of catching polio.

New York state health officials confirmed last month that an unvaccinated adult in Rockland County, a suburb of New York City, caught polio and suffered paralysis. Polio was subsequently detected in sewage in Rockland County and neighboring Orange County.

The strain that the unvaccinated adult caught is genetically linked to the sewage samples in Rockland and Orange counties. It’s unclear where the chain of transmission began, but health officials have said the sewage samples indicate there’s local spread of the virus in the New York City metropolitan area.

One in 25 people who catch polio develop viral meningitis and 1 in 200 will become paralyzed, according to health officials. Most people who catch polio do not develop symptoms, though some have symptoms similar to the flu such as sore throat, fever, fatigue, nausea and stomach pain. There is no cure for the disease, but it can be prevented through vaccination.

“The risk to New Yorkers is real but the defense is so simple – get vaccinated against polio,” said New York City Health Commissioner Dr. Ashwin Vasan.

Children should receive four doses of the vaccine: One dose at 6 weeks through 2 months, a second dose at 4 months, a third at 6 months through 18 months, and a fourth at ages 4 to 6 years old, according to New York state health officials.

People who are unvaccinated and older than age 4 should receive three doses of the vaccine. Adults who have received only one or two should get another one or two, no matter how long it has been since the earlier doses.

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More than 10,000 Americans have now tested positive in the monkeypox outbreak across the U.S., according to figures publ...
08/13/2022

More than 10,000 Americans have now tested positive in the monkeypox outbreak across the U.S., according to figures published late Wednesday by the Centers for Disease Control and Prevention, as federal health officials say they are still racing to contain the virus.

Cases have been reported in every state but Wyoming while 15 states and the District of Columbia have reported more than a hundred cases. The largest numbers are in New York, California and Florida.

No U.S. deaths have so far been reported, out of the 12 monkeypox fatalities the World Health Organization has tallied so far this year.

Health officials say the virus is mostly spreading through close interactions between men who have s*x with men, either through direct skin-to-skin contact or shared linens like towels and bedding.

However, the CDC has tallied at least 50 cases in people who were female at birth, including at least one pregnant woman. A handful of suspected infections have also been spotted in young children, although health authorities recently said some may have actually been false positives.

Federal health authorities have warned for weeks that they expected the U.S. outbreak to accelerate through August, especially as availability of testing ramped up, following the course of some other European countries that saw cases swell earlier in the year.

The U.S. has reported the most infections of any country in the world since late July. The American sum of cases is now roughly double the size of Spain, the European nation that had previously reported the most cases ahead of Germany and the United Kingdom.

The pace of new cases now appears to be slowing in some countries abroad. When measured relative to the size of each nation's population, the CDC's tally is still smaller than in those European nations, though the accelerating U.S. outbreak now appears on pace to eclipse those rates too.

For states with more than 25 cases, CDC officials recently estimated that the pace of new monkeypox infections is doubling every 8.6 days on average.

On Wednesday, 1,391 new cases were reported nationwide to the CDC — the largest single-day increase so far. The first known case in the current U.S. outbreak was reported in mid-May.

"We are still operating under a containment goal, although I know many states are starting to wonder if we're shifting to more of a mitigation phase right now, given that our case counts are still rising rapidly," Jennifer McQuiston, the CDC's top monkeypox official, told a group of the agency's outside advisers on Tuesday.

That effort might get easier over the coming weeks, following a move by the Food and Drug Administration this week to grant emergency use authorization to a method of using smaller doses of the Jynneos monkeypox vaccine that could effectively multiply the U.S. supply of the shots.

By administering these smaller doses between the skin's layers, instead of deeper into the arm, authorities say it may be possible to vaccinate up to five times as many people with each vial and still yield a "nearly identical" immune response.

However, the CDC has long warned there was limited data showing how effective the Jynneos vaccine is at actually curbing monkeypox disease and transmission — urging those vaccinated to continue taking "steps to protect themselves from infection" during the outbreak.

The agency has previously reported on a handful of reports of reported breakthrough infections following at least one shot of the two-dose Jynneos vaccine. Early data from France, where the vaccine is branded as Imvanex, also tallied breakthrough infections.

Local health officials caution it will take time for them to ramp up the new "intradermal" approach to vaccinations, which relies on different needles and procedures than the traditional "subcutaneous" shot.

"We won't just sort of say 'start.' We will make sure people will have updated provider agreements, updated training requirements, all of this. And you know, our first call with the CDC about this is on Friday, just to give you a sense that this is a process. It's not, 'here's the EUA, go'," Dr. Allison Arwady, Chicago's top health official.

Arwady, who is the vice chair of the Big Cities Health Coalition, estimated that around the country it could take up to three weeks for local health departments to begin the new dose-sparing approach.

Citing limited supply, the CDC currently says it does not encourage "mass vaccination for the general public or for all s*xually active people." Instead, the agency says shots should be prioritized first for people with HIV, pregnant and very young people, and others who are considered at high risk for severe disease.

But with supply now growing in the wake of the FDA's move, McQuiston said the CDC might soon move to expand eligibility for the shots to broader groups of people.

Officials are also weighing use of the older ACAM2000 vaccine, despite concerns that it carries some more side effects and risks than Jynneos.

"There are millions of doses of ACAM2000 in the system. And some of our modeling here at CDC suggests that it could play an important role in bringing this outbreak to a close, if it was used carefully," said McQuiston.

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In a recent study posted to the bioRxiv* preprint server, researchers evaluated all the features, especially the antigen...
08/13/2022

In a recent study posted to the bioRxiv* preprint server, researchers evaluated all the features, especially the antigenic properties and transmission potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sub-variant BA.2.75.

Background
Omicron subvariant BA.2.75, a descendent of Omiron sub-variant BA.2, is phylogenetically different from its currently predominant descendent BA.5. It is crucial to investigate its virological properties to confirm whether it poses more threat to global public health than its parent strain BA.2 and other Omicron sub-variants, including BA.5.

Specifically, studies should assess whether BA.2.75 has an increased growth efficiency in the human population, higher pathogenicity, and humoral immunity evasion potential. The phenotype of the S protein is a key determinant of viral pathogenicity; therefore, studies have assessed the resistance to antiviral humoral immunity using substitutions in the spike (S) protein. For instance, studies have demonstrated that BA.2 and BA.5 sub-variants are resistant to BA.1- and BA.2 breakthrough infection sera, respectively. BA.2.75 might likely be acquiring immune resistance to previously dominant variants to outcompete them.

Preliminary studies on BA.2.75 have also shown a potential increase in its relative effective reproduction number (Re) value compared to BA.5 and the original BA.2, raising concerns that it may soon outcompete BA.5 and be the next dominant SARS-CoV-2 variant shortly. On July 23, 2022, Nextstrain classified BA.2.75 as a new clade, 22D. Compared to the BA.2 S, BA.4/5 bears four mutations in its S protein, while BA.2.75 has nine mutations, viz., K147E, W152R, F157L, I210V, G257S, and D339H, G446S, N460K, and R493Q.

Five of these mutations are located inside the N-terminal domain (NTD), and the remaining are nested inside the receptor-binding domain (RBD). Some of these RBD mutations might be responsible for its altered neutralization sensitivity towards therapeutic monoclonal antibodies (mAbs) derived from sera of BA.2 and BA.5-infected individuals. Overall, the emergence of BA.2.75 has raised concerns that SARS-CoV-2 is continuously evolving to escape from neutralization by vaccination or infection-induced antibodies and clinically-used mAbs.

About the study
In the present study, researchers comprehensively characterized the Omicron BA.2.75 sub-variant, including its growth rate in humans, humoral immunity evasion potential, resistance to antiviral compounds, functions of its S protein in vitro, and inherent pathogenicity. They constructed a Bayesian hierarchical model to compare the relative Re between BA.5 and BA.2.75 in India, accounting for the regional differences.

Further, the researchers produced pseudoviruses bearing S proteins of Omicron sub-variants – B.1.1, BA.2, BA.5, and BA.2.75 to test their sensitivity to human sera from vaccinated and SARS-CoV-2 infected individuals. They also assessed the neutralization sensitivity of sera from infected hamsters at 16 days postinfection (d.p.i). Also, they prepared the BA.2 S-based derivatives bearing BA.2.75 substitutions to delineate the substitutions responsible for the different immunogenicity of BA.2.75 S.

The researchers obtained clinical isolates of BA.2.75 and B.1.1 (as control). Next, they inoculated them into human airway organoids (AO) to evaluate the sensitivity of BA.2.75 to three antiviral drugs.

Further, the team used HEK293-ACE2/transmembrane protease, serine 2 (TMPRSS2) cells, and HEK293-ACE2 cells to assess the association of TMPRSS2 usage with the increased pseudovirus infectivity of BA.2.75. They used an enhanced surface display system to measure the angiotensin-converting enzyme 2 (ACE2) binding affinity of the RBDs of BA.2.75 and BA.2 derivatives bearing D339H, G446S, 315 N460K, and R493Q substitutions.

Study findings
Concerning its emergence, BA.2.75 emerged independently from another BA.2 descendant, BA.5. The results of cell-based fusion, airway-on-a-chip, and plaque assays showed that it acquired higher fusogenicity after it diverged from BA.2, similar to BA.5. The authors noted that the L452R substitution in BA.5 S caused higher fusogenicity. Conversely, the N460K substitution in BA.2.75 S made it more fusogenic.

Further, the authors observed that the D339H mutation, which is unique in the BA.2.75 S, contributed to its increased ACE2 binding affinity. The structural model computed by AlphaFold2 revealed that the D339H substitution influenced the position of the linoleic acid binding loop between residues 367–378 and thereby increased binding affinity to ACE2.

In vitro experiments revealed that BA.2.75 replicated more efficiently than BA.2 in alveolar epithelial cells but not in airway epithelial cells, further confirming its higher fusogenicity via S protein evolution independently of BA.5. Despite both being the descendants of BA.2, BA.2.75 and BA.5 exhibited different immunogenicity. While BA.2.75 immunogenicity was comparable to BA.2, it was highly resistant to the BA.5-induced immunity. Furthermore, its G446S mutation made it resistant to the antiviral effects of BA.2- and BA.5-infected hamster sera. The authors also noted that three of the five NTD substitutions in BA.2.75 were closely associated with its evasion potential from BA.5-induced humoral immunity. In the future, BA.2.75 might further mutate the W152 residue to evade neutralization by sera from convalescent or vaccinated individuals.

Thankfully, BA.2.75 retained the sensitivity to three major anti-SARS-CoV-2 drugs, including Remdesivir, EIDD-1931, and Nirmatrelvir, and was more sensitive to Remdesivir.

Conclusions
The systematic evaluation of the virological properties of the new SARS-CoV-2 Omicron subvariant BA.2.75 revealed that it had a higher growth rate in the human population, fusogenicity, and intrinsic pathogenicity than BA.2. It poses a greater risk to global health, and due to significantly higher Re than BA.2 and BA.5 in India, as observed via genome surveillance, the authors predicted that BA.2.75 has the potential to outcompete BA.2 and BA.5.

Due to its higher resistance to the BA.5-induced immunity, BA.2.75 might also more efficiently spread in those countries where BA.5 is circulating (e.g., Australia). Overall, the study highlighted the need for continuous and careful monitoring of BA.2.75 through worldwide cooperation for viral genomic surveillance.

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Here we go again.Just two months after the virus landed in the US, monkeypox has been declared a national public health ...
08/13/2022

Here we go again.

Just two months after the virus landed in the US, monkeypox has been declared a national public health emergency — a déjà vu nightmare for the majority of Americans who are tired of being sick and living through unprecedented times.

Even though experts don’t expect monkeypox to be the next COVID, the virus still isn’t something you want to mess with, particularly if you’re immunocompromised, pregnant, or have certain skin conditions, like eczema. But at least this time around, there are effective treatments and vaccines available for those exposed to the virus or at risk of serious disease.

We spoke to several infectious disease experts to better understand how monkeypox spreads, what activities are riskiest at this time, and how to avoid infection as cases rise globally.

“Risk is not black and white. There’s a lot of nuance around it in general, and that’s not just unique to monkeypox,” said Dr. Aniruddha Hazra, an infectious disease doctor with the University of Chicago specializing in LGBTQ health. “This is about figuring out what you feel comfortable doing while still enjoying your life and doing the things you want to do.”

There are three ways you can catch monkeypox: direct skin-to-skin contact with an infected person; touching contaminated surfaces, objects, or fabrics; and contact with respiratory secretions like mucus.

It’s still unclear whether people without symptoms can spread the virus, if urine, f***s, semen, or vaginal fluids can infect others, or how much of a role respiratory secretions play in transmission.

Direct skin-to-skin contact
The dominant way to catch and spread monkeypox is by touching an infected person who has rashes, scabs, bodily fluids, or lesions on their skin, which can resemble a tiny pimple or a pus-filled bump that can be as big as the size of a marble.

But a light brush against or even a handshake with a potentially infectious person doesn’t necessarily mean you caught the virus. It takes a lot more contact than that. So far, the majority of people who have contracted the virus in the US are men who reported having s*x with other men, though it’s unclear if transmission is occurring in these communities during other activities, too, like hugging, partying, etc.

“You have to be rubbing against somebody's body, and then they also have to have skin lesions,” said Dr. Jessica Justman, an epidemiologist and infectious disease clinician at the Columbia Mailman School of Public Health. “Shaking hands is not the same as intimate s*xual contact. It’s so brief when you shake hands with somebody that it just doesn’t make sense to me that that would actually be a way of transmission.”

The World Health Organization in July suggested that men who have s*x with men should “for the moment” reduce partners and reconsider sleeping with new people as a way to slow monkeypox spread.

Sometimes rubbing against an infected person (aside from s*x) isn’t enough to get you sick, according to Dr. Berry Pierre, an internal medicine physician who fights monkeypox misinformation on TikTok.

“Unless you have breaks in your skin, [the virus] being on your skin is not going to seal the deal,” Pierre told BuzzFeed News. “You still have to introduce it inside your body” by touching your face, mouth, nose, or ge****ls.

Still, it won’t hurt to wash your hands often, especially before and after eating. After all, we’re still in the middle of a deadly pandemic. (More than 300 people are still dying each day from COVID in the US.)

Other activities that involve extended close and skin-to-skin contact like raves and circuit parties, for example, do confer some risk, but that doesn’t mean you have to avoid these events if that’s what you enjoy doing.

“You can still enjoy yourself and have a good time, but maybe keep your shirt on or try to stick with friends or people you know throughout your time at a party or rave, etc.,” Hazra said. “Not meaning you have to deprive yourself of these experiences, but you can continue to do that but maybe in a safer way.”

Touching contaminated surfaces, objects, or fabrics
There isn’t enough data to know for sure the likelihood of contracting monkeypox by touching contaminated surfaces or materials, but one new study from Germany, published in June in the journal Eurosurveillance, shows the virus indeed survives on different surfaces — but whether these viral particles can infect someone remains unknown.

Researchers swabbed the hospital rooms of two monkeypox patients (both men in their 30s) on day four of their hospital stay and found monkeypox virus DNA on all the surfaces and materials the patients touched, with the highest loads in their bathrooms and toilet seats, as well as cabinet door handles “presumably” touched by medical staff.

Samples collected from researchers’ gloves, a soap dispenser, and a towel on one of the patients’ beds were able to infect cells in a lab dish, but the team couldn’t confirm if an actual infection is possible via contact with these surfaces, partly because we don’t know how much virus is needed to accomplish that.

A separate 2020 study found that a nurse in the UK contracted monkeypox in 2018 after touching a patient’s contaminated bedding, despite wearing a disposable apron and gloves.

It’s unclear how long monkeypox survives on different surfaces, but the CDC says that orthopoxviruses overall can survive in homelike settings for weeks or months, and that porous materials like bedding and clothing may harbor the germs for longer periods than nonporous ones like plastic, metal, and glass. One study found live monkeypox virus survived inside an infected person’s home for 15 days after they left. In general, the virus lives longer in dark, cool, and low-humidity environments.

Yet experts aren’t convinced touching contaminated surfaces is an effective means of transmission. If it was, the data would have shown that by now, especially in Europe and Canada where monkeypox has been spreading since the beginning of May, Hazra said. It is possible, however, to get sick this way if you’re living with an infected person, sharing the same surfaces and materials for hours or days at a time.

This means you don’t have to fear touching groceries or mail, riding on public transportation, trying on clothes in a store dressing room, working out in a gym, or relaxing in a spa, the experts we spoke to said — at least not at this time.

“We’re really in this realm of what’s theoretically possible versus what is practically likely to happen, and I think getting monkeypox by trying on clothing in a store that somebody who is incubating monkeypox might have tried on just seems really far, far away from something that would happen,” Justman said, “even if there were kind of a theoretical dotted line.”

“This is about direct skin-to-skin contact,” she added.

With that being said, you can take extra precautions if it makes you more comfortable.

“It’s an extremely low risk of transmission, but it’s not zero,” Pierre said of surface transmission. “That’s why we caution our patients that this is a possibility that you need to be aware of.”

The good news is that the virus is sensitive to soaps, disinfectants, detergents, and other cleaning products, the CDC says. So a simple wipe-down or wash in the laundry should destroy the virus on any surface or material, which is particularly important if you’re caring for or living with an infected person.

Airborne transmission
The current monkeypox outbreak has not revealed any evidence of airborne transmission, but that doesn’t mean it can’t or hasn’t happened.

A study of hospitalized monkeypox patients in the UK that has yet to be peer-reviewed found that five out of 15 air samples collected before and during a bedding change were positive for monkeypox. Three of the four air samples taken during a bedding change were positive, which researchers said “highlights the importance of suitable respiratory protection equipment when performing activities that may re-aerosolise infectious material within contaminated environments.”

The CDC says you can catch monkeypox by coming in contact with respiratory secretions, which could mean physically touching mucus from a sneeze, for example, or inhaling them when sharing space with a sick person.

Wearing a mask is your best option to avoid infection this way, the agency says.

However, the agency acknowledges that it’s unknown how often monkeypox is spread through respiratory secretions or when a person is most likely to spread the virus via these secretions.

Researchers from the UK study said their work “supports the theory” that monkeypox may not only be present in large respiratory droplets, but also in aerosols and suspended skin particles or dust.

Although the current outbreak is primarily driven by s*xual contact, Justman said it’s tricky to rule out airborne transmission because you share the same air space while having s*x. “But I really want to convey that for now the main risk is direct skin-to-skin contact.”

“We are always learning as we go along,” Justman said. “Monkeypox is not a brand-new virus the way COVID was, but we’ll continue to learn more and that means what we understand and what we recommend will change. That is the nature of public health recommendations that are based in science.”

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Cases of BA.2.75 Detected in Illinois. What Experts Are Saying About New COVID VariantSince the pandemic's onset more th...
08/07/2022

Cases of BA.2.75 Detected in Illinois. What Experts Are Saying About New COVID Variant

Since the pandemic's onset more than two years ago, sudden increases in COVID-19 cases have been driven by the emergence of new variants, including delta and omicron. Currently, a more contagious omicron subvariant, called BA.5, accounts for most new U.S. cases, however a separate, newer subvariant is garnering attention.

Known as BA.2.75, the subvariant may be able to evade immunity from vaccines and prior infection, scientists assert. The strain includes multiple mutations in the gene encoding for the spike protein of the virus, which allow the virus to bind to the host cell receptor more efficiently, Dr. Matthew Binnicker, director of the Clinical Virology Laboratory at Mayo Clinic, explained in an article.

Detected in India in May, the strain appears to be spreading quicker than other subvariants there and is under monitoring by both the World Health Organization as well as the Centers for Disease Control and Prevention. Cases have surfaced in at least a dozen countries, including the U.S., where numbers remain extremely low.

A total of 13 cases have been confirmed in the U.S., with three of those in Illinois, said Dr. Allison Arwady, commissioner of the Chicago Department of Public Health.

At this point, it doesn't appear the strain will lead to another major COVID wave in the U.S., but the possibility remains.

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About 20% of Americans are afraid they'll soon contract monkeypox, but there are still some significant holes in the pub...
08/07/2022

About 20% of Americans are afraid they'll soon contract monkeypox, but there are still some significant holes in the public's understanding of the virus, according to a new survey from the Annenberg Public Policy Center.

The big picture: These early stages of monkeypox outbreaks aren't nearly as dangerous as early COVID outbreaks were, but some of the challenges for public health officials — like educating people about a virus they're not familiar with, and mobilizing vaccination efforts — are similar.

By the numbers: One in five Americans are worried about getting monkeypox in the next three months, the Annenberg survey found.

Nearly half are unsure whether monkeypox is less contagious than COVID, although 69% correctly identified the way it usually spreads (through close contact with an infected person).
Two-thirds said they either don't think there's a vaccine for monkeypox, or aren’t sure. (There is a vaccine. The Biden administration said Thursday that it's allocating another 786,000 doses, on top of the more than 340,000 it distributed this month.)
Women were more worried about contracting monkeypox than men, even though the overwhelming majority of cases in the U.S. have been among men.

Between the lines: Memories of false assurances and mixed messaging about the coronavirus in the early days of the pandemic are factoring into public sentiment on monkeypox, said Kathleen Hall Jamieson, director of the Annenberg center.

"There is some suspicion scientists don’t know what they know, so that translates to higher worry," Jamieson told Axios.
Misinformation and conspiracy theories are also a problem.

12% of respondents in the Annenberg survey said they believe the monkeypox virus was probably or definitely created in a lab; 21% said they were not sure whether it was caused by exposure to a 5G signal.

The fact that the virus has so far spread primarily among men who have s*x with men has also fueled widespread perceptions that it's a s*xually transmitted infection, which it is not.

What we're watching: Perceptions of risk remain fluid and could shift if monkeypox finds new modes of transmission, or if it continues to affect children.

"If kids get it and there's been no contact with individuals at risk, then you have a completely different situation than you have now," Jamieson said.

Methodology: The Annenberg Public Policy Center survey of 1,580 adults was conducted July 12-18. The margin of error is +/- 3.3 percentage points.

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