03/03/2026
A special thank you to the Arizona Women's Board for their support in grant funding of kidney research at TGen. 💙 🧡
+++++++++
About the project: Kidney Health Blood Markers and Spatial Transcriptomic Tissue Profiling in Native Americans
This grant funds two studies to identify population-specific markers predicting kidney disease onset, progression and treatment response, with a focus on diagnostic accuracy and therapeutic decision-making for Native American patients. Native Americans are profoundly underrepresented in genomic, molecular and clinical research, resulting in “precision” medicine tools that are not truly precise for Native American patients.
Using high-throughput technology to profile more than 9,500 proteins from blood plasma, the Kidney Health Blood Markers study will dramatically enhance the ability to detect subtle molecular changes associated with disease onset and progression in the Native American populations.
Spatial Transcriptomic Profiling study will apply this technology to kidney tissue of Native American patients to map kidney disease heterogeneity, microenvironmental features, and actionable molecular pathways to develop more population-specific strategies for diagnosis, prognosis and treatment decisions.
Photo credit: Sandra Tenuto Photography Arizona Women's Board Authors Luncheon